PMID: 3756495Aug 27, 1986Paper

Involvement of brain dopamine systems on neurotensin-induced protection against stress gastric lesions

Brain Research
D E HernandezA J Prange

Abstract

We have previously demonstrated that intracisternal (i.c.) administration of neurotensin (NT), a brain and gastrointestinal tridecapeptide, potently inhibits gastric ulcer formation induced by cold-restraint stress (CRS) in rats. This study evaluated the effect of i.c. NT (17.9 nmol) or vehicle (10 microliter of 0.9% NaCl) on the development of CRS-induced gastric ulcers and on dopamine (DA) concentrations and DA turnover (DOPAC/DA) in selected brain regions after 0, 1, 2 and 3 h of CRS. As anticipated, and in confirmation of previous findings, NT significantly reduced the incidence and severity of CRS gastric ulcers in a time-dependent manner. Neurotensin significantly decreased DA concentration and DA turnover in the striatum. In the nucleus accumbens, however, NT produced a decrease in DA concentration and a concomitant increase in DA turnover after 2 and 3 h of CRS. No significant effects of brain NT on DA concentration and DA turnover were observed in the hypothalamus or olfactory tubercles. These findings suggest that the anti-ulcer effect of brain NT may be mediated, at least in part, by a differential activation of the mesolimbic and nigrostriatal DA systems.

References

May 1, 1977·Physiology & Behavior·S C BoydB K Bowen
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·D E HernandezA J Prange
Dec 10, 1984·Life Sciences·D E HernandezA J Prange
May 1, 1982·Regulatory Peptides·J R McDermottE C Griffiths

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Citations

Dec 1, 1994·Journal of Gastroenterology·N KawakitaY Saitoh
Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Jan 1, 1988·Physiology & Behavior·A RayR M Sullivan
Sep 1, 1991·Brain Research. Brain Research Reviews·G B GlavinD E Hernandez
Dec 1, 1994·General Pharmacology·N ErinS Oktay
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J GatónA Velasco
Oct 27, 1997·American Journal of Surgery·G L Kauffman
Aug 23, 2002·Behavioural Brain Research·Den'etsu Sutoo, Kayo Akiyama
Jan 1, 1990·Journal of Ocular Pharmacology·D E Hernandez, L Jennes
Jan 1, 1990·Annals of the New York Academy of Sciences·D E Hernandez
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·P G Henke
Sep 19, 2003·Phytotherapy Research : PTR·Yong-He ZhangBao-Shan Ku
Nov 1, 1991·Digestive Diseases and Sciences·P G HenkeR M Sullivan
Jul 6, 2010·European Journal of Pharmacology·Naila RasheedGautam Palit

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