Abstract
We have previously demonstrated that intracisternal (i.c.) administration of neurotensin (NT), a brain and gastrointestinal tridecapeptide, potently inhibits gastric ulcer formation induced by cold-restraint stress (CRS) in rats. This study evaluated the effect of i.c. NT (17.9 nmol) or vehicle (10 microliter of 0.9% NaCl) on the development of CRS-induced gastric ulcers and on dopamine (DA) concentrations and DA turnover (DOPAC/DA) in selected brain regions after 0, 1, 2 and 3 h of CRS. As anticipated, and in confirmation of previous findings, NT significantly reduced the incidence and severity of CRS gastric ulcers in a time-dependent manner. Neurotensin significantly decreased DA concentration and DA turnover in the striatum. In the nucleus accumbens, however, NT produced a decrease in DA concentration and a concomitant increase in DA turnover after 2 and 3 h of CRS. No significant effects of brain NT on DA concentration and DA turnover were observed in the hypothalamus or olfactory tubercles. These findings suggest that the anti-ulcer effect of brain NT may be mediated, at least in part, by a differential activation of the mesolimbic and nigrostriatal DA systems.
References
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Citations
Jan 1, 1988·Experimental Brain Research·M YamanoM Tohyama
Jan 1, 1989·Histochemistry·D E Hernandez, L Jennes
Jan 1, 1990·Digestive Diseases and Sciences·L P XingG Kauffman
Dec 1, 1994·Journal of Gastroenterology·N KawakitaY Saitoh
Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Sep 14, 1987·Life Sciences·G B Glavin, A M Dugani
Jan 1, 1988·Physiology & Behavior·A RayR M Sullivan
Sep 1, 1991·Brain Research. Brain Research Reviews·G B GlavinD E Hernandez
Dec 1, 1994·General Pharmacology·N ErinS Oktay
Sep 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J GatónA Velasco
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Aug 23, 2002·Behavioural Brain Research·Den'etsu Sutoo, Kayo Akiyama
Jul 22, 1998·Neuroscience Letters·D SutooA Matsui
Jan 1, 1990·Journal of Ocular Pharmacology·D E Hernandez, L Jennes
Jan 1, 1990·Annals of the New York Academy of Sciences·D E Hernandez
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Sep 19, 2003·Phytotherapy Research : PTR·Yong-He ZhangBao-Shan Ku
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Apr 21, 1987·Brain Research·A RayR M Sullivan
Jul 6, 2010·European Journal of Pharmacology·Naila RasheedGautam Palit