Involvement of Brca2 in DNA repair

Molecular Cell
K J PatelAshok R Venkitaraman

Abstract

Abnormalities precipitated by a targeted truncation in the murine gene Brca2 define its involvement in DNA repair. In culture, cells harboring truncated Brca2 exhibit a proliferative impediment that worsens with successive passages. Arrest in the G1 and G2/M phases is accompanied by elevated p53 and p21 expression. Increased sensitivity to genotoxic agents, particularly ultraviolet light and methylmethanesulfonate, shows that Brca2 function is essential for the ability to survive DNA damage. But checkpoint activation and apoptotic mechanisms are largely unaffected, thereby implicating Brca2 in repair. This is substantiated by the spontaneous accumulation of chromosomal abnormalities, including breaks and aberrant chromatid exchanges. These findings define a function of Brca2 in DNA repair, whose loss precipitates replicative failure, mutagen sensitivity, and genetic instability reminiscent of Bloom syndrome and Fanconi anemia.

References

Jan 1, 1975·Cytogenetics and Cell Genetics·M M CohenG Kohn
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S J KuerbitzM B Kastan
Aug 5, 1992·Journal of the National Cancer Institute·J H Doroshow
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B Painter, B R Young
May 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·F Zampetti-Bosseler, D Scott
Jul 1, 1981·Acta paediatrica Scandinavica·C M WeemaesR D Taalman
Oct 12, 1995·Nature·J BrugarolasG J Hannon
Jun 1, 1995·Immunology Today·W C Lin, S Desiderio
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L AgarwalG R Stark
Feb 1, 1995·Current Opinion in Genetics & Development·A W Murray
Jul 1, 1994·Current Biology : CB·A EhlichK Rajewsky
Mar 1, 1996·Nature Genetics·S V TavtigianD E Goldgar
Jul 12, 1996·Cell·C BarlowA Wynshaw-Boris
Jan 24, 1997·Cell·R ScullyD M Livingston
Feb 7, 1997·Cell·A G PaulovichL H Hartwell
Apr 24, 1997·Nature·K W Kinzler, B Vogelstein
Apr 24, 1997·Nature·J MilnerT Kouzarides
May 15, 1997·Genes & Development·A SuzukiT W Mak
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MizutaF W Alt

❮ Previous
Next ❯

Citations

Jan 19, 1999·Genes, Chromosomes & Cancer·M TirkkonenA Borg
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C X Deng, S G Brodie
Jun 16, 2001·Cell Biology International·S K KachhapS N Ghosh
Jun 15, 2011·Breast Cancer Research and Treatment·Cristina BaliaMaria Adelaide Caligo
Dec 29, 2012·Cancer Causes & Control : CCC·Jayeon Kim, Kutluk Oktay
Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Tatiana Garcia-Muse, Simon J Boulton
Jun 1, 2006·Familial Cancer·William D Foulkes
Aug 31, 2010·Irish Journal of Medical Science·E M Y Saleh, R A E El-Awady
Sep 14, 2011·Current Oncology Reports·Susana Banerjee, Stan Kaye
May 29, 2013·Cell Biochemistry and Biophysics·Xavier JacqStephen P Jackson
Jan 29, 2013·Molecular Biotechnology·Emilia VuttarielloGennaro Chiappetta
Feb 6, 2009·Pathology Oncology Research : POR·Rachel E EllsworthCraig D Shriver
Feb 14, 2013·Pathology Oncology Research : POR·Agnieszka SassiKatarzyna Wozniak
Feb 22, 2011·Cellular Oncology (Dordrecht)·Petra van der GroepPaul J van Diest
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Martha TorresGhazi Alsbeih
Jun 27, 2002·Biochemical and Biophysical Research Communications·Chiang WangMitchell S Steiner
Apr 25, 2003·Experimental and Molecular Pathology·Alexander J R Bishop, Robert H Schiestl
Apr 23, 2003·Journal of Molecular Biology·Cecilia LundinThomas Helleday
Aug 1, 2000·Mutation Research·P SungS Van Komen
May 30, 2001·Mutation Research·L H Thompson, D Schild
Aug 17, 2001·Mutation Research·A PastinkP H Lohman
Nov 13, 2002·Mutation Research·Larry H Thompson, David Schild
Nov 9, 2002·Lancet·Ashok R Venkitaraman
Mar 20, 2002·Biochimie·Ralph Scully, Nadine Puget
Oct 20, 1999·Mutation Research·A Shinohara, T Ogawa
May 10, 2001·Current Opinion in Cell Biology·A R Venkitaraman
Apr 8, 2000·Current Opinion in Genetics & Development·P Karran
May 3, 2003·Current Opinion in Structural Biology·Yousif Shamoo
Nov 5, 2002·Critical Reviews in Oncology/hematology·F Lerebours, R Lidereau
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·C Morrison, S Takeda
Jul 29, 1998·Molecular Medicine Today·J Feunteun
Dec 10, 2002·Trends in Molecular Medicine·Andrew Tutt, Alan Ashworth
Jan 18, 2003·DNA Repair·Stephen C West
May 28, 2003·DNA Repair·John Thacker, Małgorzata Z Zdzienicka
Dec 2, 2000·Nature·R Scully, D M Livingston
Jul 9, 2008·Nature Medicine·Sergey G KuznetsovShyam K Sharan
Sep 17, 2013·Nature Neuroscience·Wen-Yuan WangLi-Huei Tsai
Sep 3, 2004·Nature Reviews. Cancer·Steven A Narod, William D Foulkes
Feb 8, 2008·Nature Reviews. Cancer·Thomas HelledayRicky A Sharma
Oct 15, 2010·Nature Reviews. Cancer·David D L Bowtell
Apr 22, 2011·Nature Reviews. Cancer·Guillaume LambertRobert H Austin

❮ Previous
Next ❯

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