PMID: 9547349May 9, 1998Paper

Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

Molecular Pharmacology
C GajateF Mollinedo

Abstract

The ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3; edelfosine) is a potent inducer of apoptosis in human tumor cells. We show that ET-18-OCH3-induced apoptosis is associated with activation of the c-Jun NH2-terminal kinase (JNK) signaling. The addition of ET-18-OCH3 to distinct human leukemic cells (HL-60, U937, and Jurkat), which undergo rapid apoptosis on treatment with ET-18-OCH3, induced a dramatic and sustained increase in the of c-jun mRNA level that was associated with activation of activator protein-1 transcription factor. We found that ET-18-OCH3 induced a persistent activation of JNK in HL-60 cells that was detected before the onset of apoptosis, the latter being assessed by DNA fragmentation and by the appearance of phosphatidylserine on the external leaflet of the plasma membrane. The inductions of JNK after HL-60 monocyte/macrophage differentiation and ET-18-OCH3-mediated apoptosis were distinguished by the different activation patterns, transient versus persistent, respectively. ET-18-OCH3 analogues unable to induce apoptosis failed to activate JNK. ET-18-OCH3-dependent JNK activation was not detected in K562 cells, which did not undergo apoptosis on treatment with ET-18-OCH3...Continue Reading

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Dec 16, 1991·Biochemical and Biophysical Research Communications·C GiannakisP D Zalewski
Sep 1, 1991·European Journal of Biochemistry·F Mollinedo, J R Naranjo
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L LokeL M Neckers
Jul 14, 1995·The Journal of Biological Chemistry·M Karin
May 1, 1995·Medicinal Research Reviews·W J HoulihanS H Cheon
Dec 1, 1994·Molecular and Cellular Biology·H K SlussR J Davis
Jun 1, 1994·International Journal of Cancer. Journal International Du Cancer·L DiomedeM Salmona
Apr 30, 1993·Biochemical and Biophysical Research Communications·F MollinedoM Modolell
Jan 5, 1996·Biochemical and Biophysical Research Communications·C GajateF Mollinedo

❮ Previous
Next ❯

Citations

Mar 4, 2000·International Journal of Cancer. Journal International Du Cancer·C GajateF Mollinedo
Jul 14, 2006·The Biochemical Journal·Laura RomeroGordon Kirby
Jun 4, 2013·Blood Cancer Journal·M Reis-SobreiroF Mollinedo
Feb 24, 2015·Apoptosis : an International Journal on Programmed Cell Death·Consuelo Gajate, Faustino Mollinedo
May 15, 2010·Future Oncology·Faustino Mollinedo, Consuelo Gajate
Jan 1, 2002·Environmental Health and Preventive Medicine·Masato Matsuoka, Hideki Igisu
Oct 3, 1999·Carcinogenesis·Y SatomiM N Gould
Mar 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marcia M WrightVanina Zaremberg
Apr 28, 2006·FEBS Letters·Bohdana Heczková, J Peter Slotte
Mar 25, 2010·British Journal of Pharmacology·Kerstin DankerGeo Semini
Apr 17, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Pranati SamadderGilbert Arthur
Jul 8, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M RenisA Russo
Mar 10, 2007·Apoptosis : an International Journal on Programmed Cell Death·Caroline ParisJacqueline Bréard
Mar 17, 2006·The Journal of Biological Chemistry·Teresa Nieto-MiguelFaustino Mollinedo
Mar 30, 2000·International Journal of Cancer. Journal International Du Cancer·C GajateF Mollinedo
Nov 3, 2007·Cancer Research·Teresa Nieto-MiguelFaustino Mollinedo
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ander Estella-Hermoso de MendozaMaría J Blanco-Prieto
Oct 30, 1998·Biochemical and Biophysical Research Communications·M Matsuoka, H Igisu
Feb 15, 2001·International Journal of Radiation Oncology, Biology, Physics·G A RuiterW J van Blitterswijk
Jan 18, 2003·Biochimica Et Biophysica Acta·Zheng Cui, Martin Houweling
May 29, 2004·Biochimica Et Biophysica Acta·Michiel H M van der SandenLambert M G van Golde
Jul 1, 2006·Environmental Toxicology and Pharmacology·Katharine M W Haberstroh, Carolyn M Kapron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis