Involvement of calmodulin inhibition in analgesia induced with low doses of intrathecal trifluoperazine

Japanese Journal of Pharmacology
Saeid GolbidiValiollahe Hajhashemi

Abstract

We examined which of the known properties of trifluoperazine, including calmodulin inhibition, are involved in its analgesic effect. Furthermore, we tried to find any possible interaction between opioidergic system and calmodulin inhibition-induced analgesia. Intrathecal trifluoperazine (1, 10, 100 microg) showed a biphasic effect in the formalin test; i.e., analgesia at relatively low doses (1, 10 microg) and hyperalgesia at a high dose (100 microg). No analgesic effects were observed after intrathecal injection of sulpiride (1, 10, 100 microg), atropine (0.1, 1, 10 microg), phentolamine (0.1, 1, 10 microg) and brompheniramine (0.1, 1, 10 microg). Meanwhile, intrathecal calmidazolium (10, 50, 250 microg) induced a dose-dependent analgesia. Histamine (1 microg), physostigmine (1 microg), bromocriptine (1 microg) and norepinephrine (1 microg) did not affect trifluoperazine-induced analgesia. Calcium (20 microg) attenuated the antinociceptive effect of trifluoperazine and inhibited the analgesic effect of calmidazolium. Finally, naloxone (2 mg/kg) decreased trifluoperazine-induced antinociception but did not have any effects on calmidazolium-induced analgesia. We concluded that calmodulin inhibition may be involved in the analges...Continue Reading

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Citations

May 30, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yan ChenZaijie Jim Wang
Jun 30, 2006·Journal of Neurophysiology·Patrick L SheetsTheodore R Cummins
Feb 3, 2012·CNS Drugs·Elena P Calandre, Fernando Rico-Villademoros
Jan 8, 2008·The Journal of Pharmacology and Experimental Therapeutics·Fang LuoZaijie Jim Wang
Nov 14, 2007·Expert Review of Neurotherapeutics·Theodore R Cummins, Anthony M Rush

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