Involvement of cAMP and cGMP in the mode of action of molt-inhibiting hormone (MIH) a neuropeptide which inhibits steroidogenesis in a crab

Molecular and Cellular Endocrinology
B SaïdiF Lachaise

Abstract

In crustaceans, production of molting hormones (or ecdysteroids) by the molting glands (Y-organs; YO), is under negative control exerted by a neuropeptide, the molt-inhibiting hormone (MIH). MIH of the crab Carcinus maenas inhibits in vitro steroidogenesis of basal (intermolt crab) or activated (premolt crab) YO. MIH inhibits secretion of the two ecdysteroids synthesized by crab YO, ecdysone (E) secreted throughout the molting cycle, and 25-deoxyecdysone (25dE), secreted during the premolt period. At a MIH concentration of 10(-8) M, E is reduced about 50% and 25dE 94%. Regardless of the molting stage, this inhibition of steroidogenesis is reversible, dose dependent and measurable after 5 min. On intermolt YO, MIH induced cGMP increase and 8BrcGMP mimics the effect of MIH: at this stage cGMP seems to be involved with MIH inhibition of steroidogenesis. On premolt YO MIH induced a transient increase of cAMP (2-fold) and a long-lasting enhancement of cGMP (60-fold). On active YO, we demonstrated that a low concentration (10(-5) M) of dbcAMP, 8BrcAMP, 8BrcGMP, or agents increasing intracellular cAMP, mimic MIH effects and inhibit steroidogenesis. From these observations it is concluded that both cyclic nucleotides are involved in th...Continue Reading

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Citations

Aug 1, 1996·Endocrine·F LachaiseD Baghdassarian
Mar 1, 1995·Molecular and Cellular Endocrinology·C Dauphin-VillemantD Sedlmeier
Apr 22, 1997·Proceedings. Biological Sciences·L O LomasH H Rees
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May 10, 2005·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Deug-Woo Han, R Douglas Watson
Feb 24, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Deug-Woo HanR Douglas Watson
Oct 30, 2020·Frontiers in Endocrinology·Hsiang-Yin ChenChi-Ying Lee
Jan 24, 2006·General and Comparative Endocrinology·Junying ZhengR Douglas Watson
Nov 13, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Teruaki NakatsujiR Douglas Watson
Jan 13, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Joseph A CoviDonald L Mykles
Sep 17, 2021·General and Comparative Endocrinology·Amanda C WeinerR Douglas Watson

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