Involvement of catecholaminergic and cholinergic mechanisms in the pulsatile release of LH in the long-term ovariectomized rat

H P Gnodde, G A Schuiling


In the long-term ovariectomized rat the secretion of LH has a pulsatile character. In such rats no difference was observed between morning and afternoon LH secretion. The administration of phenoxybenzamine, an chi-adrenergic blocker, resulted in depressed plasma LH levels. chi-Methyl-tyrosine (chi-MT), an inhibitor of tyrosine hydroxylase had no effect on plasma LH levels, whereas bis(4methyl-1-homopiperazinil-thiocarbonil) disulphide (FLA 63), an inhibitor of dopaminic-beta-hydroxylase, induced decreased plasma LH levels and disappearance of the pulsations. The same effect was observed after the administration of apomorphine, a dopaminic receptor stimulating drug, whereas the administration of 1-hydroxy-3-amino-pyrrolidone-2 (HA-966), which blocks dopamine release, significantly raised plasma LH levels. Scopolamine, a cholinergic muscarinic receptor blocking drug, had no effect on plasma LH levels, whereas mecamylamine, a cholinergic nicotine receptor blocking agent, decreased them. These results are consistent with the hypothesis that the pulsatile release of LH in the long-term ovariectomized rat is caused by the stimulating activity of adrenergic and cholinergic, probably nicotinic, systems and the inhibitory activity of a ...Continue Reading


Jan 1, 1978·Journal of Neural Transmission·H StepieńM Pawlikowski
Dec 1, 1994·Pharmacology, Biochemistry, and Behavior·A LafuenteA I Esquifino
Jan 1, 1981·Psychoneuroendocrinology·O BenkertC Seibold
Dec 15, 1981·Experientia·T R KoiterG A Schuiling
Jun 1, 1976·Molecular and Cellular Endocrinology·J de KoningG P van Rees
Oct 1, 1981·General and Comparative Endocrinology·F C BuonomoC G Scanes
Mar 1, 1983·General and Comparative Endocrinology·F C Buonomo, C G Scanes
Jun 1, 1989·Journal of Neuroendocrinology·R V GalloD O'Sullivan
Jun 1, 1983·Journal of Endocrinological Investigation·S M McCann

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Circadian Rhythms
FLA 63
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