PMID: 6405436Jan 1, 1983Paper

Involvement of catecholamines in acute tolerance to ethanol in mice

Psychopharmacology
F EdwardsO Jenkins

Abstract

The percentage of mice able to remain on a rolling drum for 45 s was recorded at 1.25 min and 30 min after administration of ethanol (2.4 g/kg). Though there was no significant difference in brain ethanol levels at the two test times, performance was markedly different with significantly fewer mice able to remain on the drum at 1.25 min than at 30 min. This phenomenon, known as acute tolerance, was antagonised by pretreating mice with haloperidol (0.4 mg/kg), FLA-63 (25 mg/kg), diethyldithiocarbamate (400 mg/kg), phenoxybenzamine (40 mg/kg), phentolamine (20 mg/kg), yohimbine (3 mg/kg) and clozapine (1 mg/kg), but not by spiperone (0.16 mg/kg), alpha-methyl-p-tyrosine (300 mg/kg) or phenobarbitone (10 mg/kg). The relative potencies of the effective blocking agents suggest that alpha 2-receptors may play an important role in mediating acute ethanol tolerance.

References

Dec 1, 1975·European Journal of Pharmacology·K StarkeT Endo
Jan 1, 1975·Psychopharmacologia·A E LeBlancR J Gibbins
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt

❮ Previous
Next ❯

Citations

Jun 1, 1986·British Journal of Addiction·D Nutt, P Glue
Jan 1, 1984·British Journal of Clinical Pharmacology·G A Starmer, K D Bird

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here