PMID: 6290901Sep 1, 1982Paper

Involvement of catecholamines in Haemophilus influenzae induced decrease of beta-adrenoceptor function

Naunyn-Schmiedeberg's Archives of Pharmacology
A J SchreursF P Nijkamp

Abstract

The deeper airways of patients with asthmatic bronchitis are often infected with Haemophilus influenzae. Vaccination of guinea pigs with H. influenzae resulted in a significant impairment of the isoproterenol induced relaxation of isolated tracheal spirals by approximately 50% 4 days following vaccination. In the present study we further investigated the effects of some drugs affecting catecholamine release on the H. influenzae induced functional desensitization of tracheal spirals. Benserazide, an inhibitor of dopa-decarboxylase, completely prevented the reduction in isoproterenol-induced relaxation after H. influenzae vaccination, while no effect on relaxation of tracheal spirals from control animals was detected. On the other hand, inhibiting the re-uptake of catecholamines with desipramine did not influence the relaxation in the H. influenzae vaccinated tracheal spirals. Treatment of control animals with desipramine however resulted in a decreased relaxation of the isolated spirals by 40%. One day following vaccination with H. influenzae the level of norepinephrine in lung tissue was significantly elevated by 71%, and in plasma by 77%, while after 4 days no significant effects were observed. The spontaneous release of norep...Continue Reading

References

Apr 7, 1977·European Journal of Pharmacology·J S DouglasA Bouhuys
Sep 15, 1978·European Journal of Pharmacology·D C U'Prichard, S H Snyder
Mar 1, 1979·Clinical and Experimental Pharmacology & Physiology·G K TerpstraJ Kreukniet
Aug 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·W H AndersonA Szentivanyi
Sep 3, 1976·Brain Research·D H VersteegM Palkovits
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MukherjeeR J Lefkowitz
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianJ Axelrod
Apr 30, 1976·Brain Research·J Van der GugtenD H Versteeg
Sep 1, 1972·The Journal of Allergy and Clinical Immunology·H G MorrisM R Earle
Oct 25, 1969·British Medical Journal·M FisherJ W Crofton
May 1, 1980·The Journal of Clinical Investigation·C J HomcyS Kopiwoda

❮ Previous
Next ❯

Citations

Feb 1, 1984·Veterinary Research Communications·A J Schreurs, F P Nijkamp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.