Jul 1, 1993

Involvement of catecholamines in the effect of U-50,488H on isolated left atria of the rat

General Pharmacology
J A Micol, M L Laorden


1. The present study examined the effect of U-50,488H on auricular contraction of isolated left atria of the rat. 2. The negative inotropic action induced by the kappa-agonist was antagonized in the presence of propranolol (10(-8) or 5 x 10(-8) M), yohimbine (5 x 10(-7) or 10(-6) M) or in reserpinized rats (5 mg/kg i.p. 24 hr before the experiments). 3. These results suggest that catecholaminergic mechanisms are involved in the cardiac depressant effect induced by U-50,488H.

  • References8
  • Citations1


Mentioned in this Paper

Yohimbin Spiegel
Myocardial Contraction
Catecholamines Measurement
Contraction (Finding)
Anti-Arrhythmia Agents
Right Atrial Structure
Cardiac Depressants
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-benzeneacetamide Monomethanesulfonate, (trans)-Isomer

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