PMID: 7537538Feb 1, 1995Paper

Involvement of CD5 in Th1 and Th2 contact-mediated rescue of anti-mu and ionomycin induced growth inhibition in a B cell lymphoma

International Immunology
S Muthukkumar, S Bondada

Abstract

Cross-linking of membrane Ig receptors by anti-mu antibodies (Ab) or treatment with ionomycin induced complete growth arrest and subsequent apoptotic cell death in an immature B cell lymphoma, BKS-2. The growth-inhibitory signals delivered by anti-mu and ionomycin were overcome by anti-CD3-activated Th2 clones D10.G4 and F1 and by Th1 cell clone S53. In this report the Th-mediated growth reversal in BKS-2 cells was shown to require contact-dependent interactions when the inhibition was caused by immobilized anti-mu or ionomycin. Th2 cells in transwells (lymphokines) failed to protect BKS-2 cells from the growth-inhibitory effect of immobilized anti-mu or ionomycin. Monoclonal antibodies to CD5 or CD40 ligands on activated Th cells partially inhibited the Th2 contact-dependent growth reversal of BKS-2 cells whereas simultaneous addition of both antibodies effectively prevented the delivery of contact-mediated growth signal. In contrast, anti-class I or class II Ab did not affect Th cell mediated growth reversal of BKS-2 cells. These data demonstrated that noncognate physical interaction with Th cells was essential for the recovery of BKS-2 cells when the latter were growth-arrested by strong inhibitory stimuli such as immobilize...Continue Reading

Citations

Aug 1, 1997·Molecular Immunology·S MuthukkumarS Bondada
Feb 13, 1999·The European Journal of Neuroscience·A C LinthorstM H Reul
Nov 5, 1997·The Journal of Biological Chemistry·S MuthukkumarS Bondada
Dec 24, 1997·Acta Paediatrica. Supplement·I Berczi
Jun 15, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M M SarwalO Salvatierra
Oct 21, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S S HanS Bondada

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