PMID: 26838213Feb 4, 2016Paper

Involvement of CELSR3 Hypermethylation in Primary Oral Squamous Cell Carcinoma

Asian Pacific Journal of Cancer Prevention : APJCP
Goot Heah KhorThong Kwai Lin

Abstract

Promoter hypermethylation is a frequent epigenetic mechanism for gene transcription repression in cancer and is one of the hallmarks of the disease. Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) contributes to cell contact-mediated communication. Dysregulation of promoter methylation has been reported in various cancers. The objectives of this study were to investigate the CELSR3 hypermethylation level in oral squamous cell carcinomas (OSCCs) using methylation-sensitive high-resolution melting analysis (MS-HRM) and to correlate CELSR3 methylation with patient demographic and clinicopathological parameters. Frozen tissue samples of healthy subjects' normal mucosa and OSCCs were examined with regard to their methylation levels of the CELSR3 gene using MS-HRM. MS-HRM analysis revealed a high methylation level of CELSR3 in 86% of OSCC cases. Significant correlations were found between CELSR3 quantitative methylation levels with patient ethnicity (P=0.005), age (P=0.024) and pathological stages (P=0.004). A moderate positive correlation between CELSR3 and patient age was also evident (R=0.444, P=0.001). CELSR3 promoter hypermethylation may be an important mechanism involved in oral carcinogenesis. It may thus be used as a b...Continue Reading

References

Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Nov 25, 2004·The Oncologist·Mary Cianfrocca, Lori J Goldstein
Mar 22, 2005·Nature Neuroscience·Fadel TissirAndre M Goffinet
Feb 24, 2006·Nature Reviews. Cancer·Stephen B Baylin, Joyce E Ohm
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jun 15, 2007·Pharmacogenomics·Gudrun H ReedCarl T Wittwer
Oct 17, 2007·Annual Review of Medicine·Einav Nili Gal-YamPeter A Jones
Jan 31, 2009·Nature Protocols·Tomasz K WojdaczLise Lotte Hansen
May 30, 2009·Human Mutation·Carl T Wittwer
Jun 2, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Tomasz K WojdaczLise Lotte Hansen
Mar 11, 2010·Expert Review of Molecular Diagnostics·Jesse L MontgomeryCarl T Wittwer
Jul 16, 2010·Expert Review of Molecular Diagnostics·Tomasz K WojdaczLise Lotte Hansen
Jan 12, 2012·Neuroscience Bulletin·Ruiping Xia, Zhi-Hong Mao
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jing ShenRegina M Santella
Mar 13, 2012·International Journal of Molecular Sciences·Massimo MascoloStefania Staibano
Nov 7, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Goot Heah KhorKwai Lin Thong
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Xiang-Yang TianMing Li

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Citations

Mar 20, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria Giulia BacaliniPaolo Garagnani
May 26, 2018·Scientific Reports·David J SchultzCarolyn M Klinge
Apr 4, 2021·Journal of Cellular and Molecular Medicine·Yishuai LiShujun Li
Apr 8, 2020·ACS Pharmacology & Translational Science·Abanoub A Gad, Nariman Balenga

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