Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats.

Psychopharmacology
F ChaperonMarie-Hélène Thiébot

Abstract

The involvement of cannabinoid processes in positive reinforcement was studied using an unbiased, one-compartment, conditioned place preference (CPP) procedure in rats. This was achieved by examining the ability of the selective antagonist of the CB1 cannabinoid receptor subtype, SR 141716, to counteract the CPP supported by classical reinforcers. The acquisition of CPP induced by cocaine (2 mg/kg), morphine (4 mg/kg) and food (standard chow and sucrose pellets) was dose-dependently blocked by pre-pairing administration of SR 141716 (0.03-3 mg/kg). However, SR 141716 (up to 10 mg/kg) did not significantly counteract the expression of cocaine-induced CPP. On the other hand, the synthetic CB receptor agonist, WIN 55212-2 (0.3-1 mg/kg), established a robust place aversion (CPA), as already described with other agonists, and CPP was never observed, even at 100-fold lower doses. The aversive effect of WIN 55212-2 was reversed by SR 141716 (0.3-1 mg/kg), suggesting that it was accounted for by the stimulation of CB1 receptors. These findings indicate that, on their own, CB receptor agonists are unable to generate the processes necessary to induce a pleasurable state in animals, as assessed in place conditioning procedures. Neverthele...Continue Reading

Citations

Apr 12, 2005·Psychopharmacology·Zoë D Thornton-JonesPeter G Clifton
Apr 12, 2005·Psychopharmacology·Styliani VlachouGeorge Panagis
Jun 30, 2005·Psychopharmacology·Benoît ForgetMarie-Hélène Thiébot
Feb 24, 2006·Psychopharmacology·Gian Luigi GessaGiancarlo Colombo
Sep 6, 2006·Psychopharmacology·Styliani VlachouGeorge Panagis
May 26, 2009·Psychopharmacology·Benoît ForgetMarie-Hélène Thiébot
May 19, 2007·Biological Psychiatry·Lingjun ZuoJoel Gelernter
May 27, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Matthew N Hill, Boris B Gorzalka
Jun 7, 2005·Life Sciences·Mauro A M CaraiGian Luigi Gessa
Jun 11, 2005·Life Sciences·Cecilia J Hillard
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·Daniela ViganòDaniela Parolaro
Jun 9, 2005·Pharmacology, Biochemistry, and Behavior·Giancarlo ColomboGian Luigi Gessa
Jun 4, 2005·Pharmacology, Biochemistry, and Behavior·Zuzana JustinovaGianluigi Tanda
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