Involvement of central neurotransmission systems in schizophrenia

Thérapie
Marie-Pascale Martres

Abstract

Psychiatric disorders have a high prevalence in all countries and cultures and have a high cost in socio-economic terms. The participation of dopaminergic neurotransmission in the pathophysiology of schizophrenia is well known. However, until recently, the nature of dopaminergic dysfunctions had not been elucidated. Several recent lines of evidence show that (i) the phasic dopaminerginergic neurotransmission (as opposed to the tonic) is altered in schizophrenia and (ii) such dysfunction does not participate in the aetiology of the disease, but is rather the consequence of other dysfunctions. Although the role of serotonergic neurotransmission in mood disorders is well known, its involvement in schizophrenia is not well documented and is supported only by indirect evidence. Finally, the role of glutamatergic neurotransmission in the pathophysiology of schizophrenia, previously hindered by the lack of selective tools, has been supported by recent studies, but needs to be confirmed by further works before definite conclusions can be reached.

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·D LévesqueJ C Schwartz
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M LaruelleR B Innis
Feb 7, 1997·Schizophrenia Research·M H Dao-CastellanaJ L Martinot
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·A BreierD Pickar
Jan 28, 1998·Critical Reviews in Neurobiology·C A Tamminga
Dec 4, 1998·Biological Psychiatry·J A LiebermanJ E Kraus
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·P Seeman, S Kapur
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A Abi-DarghamM Laruelle
Dec 18, 2001·Biological Psychiatry·D R WeinbergerT E Goldberg
Feb 28, 2002·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Apr 23, 2004·Trends in Neurosciences·Robert T FremeauRobert H Edwards
Feb 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Philip SeemanTeresa Tallerico
Sep 27, 2005·Neuropharmacology·Christelle GrasSalah El Mestikawy
Feb 16, 2006·Biological Psychiatry·Elizabeth M TunbridgeDaniel R Weinberger
Jun 21, 2006·Synapse·Philip SeemanTomiki Sumiyoshi
May 29, 2007·Biological Psychiatry·Corrado CortiFrancesco Ferraguti
Jun 15, 2007·Synapse·Mélina BégouMarie-Françoise Suaud-Chagny

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