PMID: 9416730Jan 7, 1998Paper

Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat

Anesthesiology
M J FuS H Chan

Abstract

Investigators in the authors' laboratory previously established the critical participation of the cerulospinal noradrenergic pathway in muscular rigidity elicited by fentanyl. The identification of colocalization of glutamate with tyrosine hydroxylase in most locus ceruleus neurons suggests a role for cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity. This suggestion and the subtype(s) of glutamate receptors involved were investigated here. Electromyographic signals activated by bilateral microinjection of 2.5 microg fentanyl into the locus ceruleus were recorded differentially from the left sacrococcygeus dorsi lateralis muscle of adult male Sprague-Dawley rats. The effect of intrathecal administration at the lower lumbar spinal cord of various N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists or agonists on this index of muscular rigidity was studied. Rats were under mechanical ventilation, and intravenous infusion of ketamine (30 mg x kg(-1) x h(-1)) was maintained until 10 min before fentanyl was administered. Microinjection of fentanyl bilaterally into the locus ceruleus increased the root mean square and decreased the mean power frequency values of electromyographic signals. Th...Continue Reading

References

Jan 1, 1991·Progress in Brain Research·M J Christie
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·B C WangH Turndorf
Feb 1, 1990·Trends in Pharmacological Sciences·D Lodge, K M Johnson
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M MiyakeR A North
Jul 1, 1987·Neuropharmacology·L L WerlingB M Cox
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Feb 1, 1974·European Journal of Pharmacology·J KorfG K Aghajanian
Apr 1, 1983·Neuropharmacology·J W VilligerK M Taylor
Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
May 1, 1981·Anesthesia and Analgesia·M K ComstockW C Stevens
Mar 1, 1995·Pharmacology, Biochemistry, and Behavior·N J ChangJ B Dyck
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·M B Weinger, J M Bednarczyk

❮ Previous
Next ❯

Citations

Jan 8, 1999·Peptides·G A OlsonA J Kastin
Aug 7, 2001·British Journal of Pharmacology·F AdamF Guirimand
Jan 31, 2002·Anesthesiology·Jan De Witte, Daniel I Sessler
Mar 15, 2012·Veterinary Anaesthesia and Analgesia·René DörfeltYves Moens
Sep 20, 2005·Epilepsy & Behavior : E&B·Phillip C Jobe, Ronald A Browning
Sep 17, 2004·Regional Anesthesia and Pain Medicine·Yukari SudohGing Kuo Wang
Nov 20, 2002·BMC Neuroscience·Parham GharagozlouJelveh Lameh
Oct 4, 2016·Clinical and Experimental Pharmacology & Physiology·SangMin ChoeGyu-Jeong Noh
May 7, 2002·British Journal of Anaesthesia·G B Drummond, M K Duncan
Sep 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Randy Torralva, Aaron Janowsky
Jun 10, 2020·The Journal of Pharmacology and Experimental Therapeutics·Randy TorralvaAaron Janowsky
Jun 11, 2021·Journal of Clinical Pharmacy and Therapeutics·Joseph V PergolizziRobert B Raffa
May 25, 2021·British Journal of Pharmacology·Eamonn KellyGraeme Henderson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.