Involvement of chemokine receptor CCR6 in colorectal cancer metastasis

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Claudia RubieMartin K Schilling

Abstract

Various chemokine receptors, namely CXCR4, CCR6 and CCR7, have recently been shown to be involved in the regulation of metastasis in malignant tumors. However, little is known about the role of these receptors in promoting tumor metastasis of colorectal cancer (CRC) to the primary site of CRC metastasis in the liver. To investigate this issue, we analyzed the expression of the chemokine receptors CXCR4, CCR6 and CCR7 in colorectal tumors and colorectal liver metastases. In the present study, 30 human cancer samples from colorectal tissue, 30 human samples from colorectal liver metastases and the adjacent nontumorous liver tissues were screened using quantitative real-time PCR, Western blot analysis, histochemistry, microdissection and the enzyme-linked immunosorbent assay (ELISA). While an overexpression of all the chemokine receptors was found in CRC, in colorectal liver metastases only the chemokine receptors CXCR4 and CCR6 were significantly upregulated. Consequently, we investigated the expression of the corresponding ligands CXCL12/SDF1alpha, CCL20/MIP3alpha, CCL19/MIP3beta and CCL21/6Ckine in various organs, such as the stomach, esophagus, pancreas, colon and rectum, in comparison with their expression in the liver as the...Continue Reading

References

Dec 1, 1995·Computer Methods and Programs in Biomedicine·F SchoonjansF H Comhaire
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D GunnL T Williams
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Dec 5, 1998·Journal of Immunological Methods·J M WangS Su
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShimizuA Watanabe
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H GeminderA Ben-Baruch
Apr 16, 2002·British Journal of Cancer·A J SchraderJ Lauber
Apr 18, 2002·Leukemia·C VoermansC E van Der Schoot
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Roderick J PhillipsRobert M Strieter
Apr 4, 2003·International Journal of Cancer. Journal International Du Cancer·Iwao Takanami
Jun 7, 2003·Scandinavian Journal of Immunology·J DellacasagrandeZ Dembic
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroya TakeuchiDave S B Hoon
Sep 25, 2004·Cancer·Eric J Suba, Stephen S Raab
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carl C SchimanskiMarkus Moehler
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph KimDave S B Hoon

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Citations

Aug 19, 2011·International Journal of Clinical Oncology·Kenji KawadaYoshiharu Sakai
Sep 28, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoshihiro MinamiyaJun-Ichi Ogawa
Jun 27, 2008·BMC Cancer·Claudia RubieMartin K Schilling
Mar 22, 2012·Journal of Translational Medicine·Alberto FusiUlrich Keilholz
May 13, 2010·Journal of Translational Medicine·Claudia RubieMartin K Schilling
Feb 26, 2011·Journal of Translational Medicine·Claudia RubieMartin K Schilling
Apr 3, 2009·PloS One·Katia BeiderAmnon Peled
Jan 21, 2011·PloS One·Mairi H McLeanEmad M El-Omar
Feb 25, 2014·Journal of Translational Medicine·Claudia RubieMathias Glanemann
Sep 10, 2014·Journal of Cellular Physiology·Chih-Chien ChinWen-Shih Huang
Dec 3, 2015·Journal of Translational Medicine·Małgorzata StecMarek Zembala
Feb 23, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·O KollmarM K Schilling
Aug 12, 2014·BioMed Research International·Jiamin ZhouJi Ming Wang
Jun 6, 2015·Cytokine·Gang HanChengjun Li
May 30, 2009·International Journal of Cancer. Journal International Du Cancer·Pirus GhadjarUlrich Keilholz
Oct 31, 2008·Scandinavian Journal of Immunology·C RubieM K Schilling
Mar 4, 2008·Journal of Cutaneous Pathology·Jeff BasileDeanne M R Lathers
Jun 25, 2013·Scandinavian Journal of Immunology·V O FrickM Glanemann
Oct 13, 2009·International Journal of Cancer. Journal International Du Cancer·Otto KollmarMartin K Schilling
Nov 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Francesca CoperchiniMario Rotondi
Feb 18, 2015·Frontiers in Immunology·Maria VelaLeonor Kremer
Oct 23, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·X G ZhangH Qu
Nov 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia RubieMathias Wagner
Jul 8, 2014·Journal of Pediatric Gastroenterology and Nutrition·Rulan JiangBo Lönnerdal
Jan 12, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xiaolei JiaoYingtang Gao
Feb 28, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Sara PączekBarbara Mroczko
Jun 29, 2012·Oncology Letters·Ketao JinFeilin Cao
Jun 25, 2016·World Journal of Gastroenterology : WJG·Xiang LiWei-Dong Han

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