Involvement of chemokine receptors in organ-specific metastasis

Contributions to Microbiology
A Zlotnik

Abstract

The chemokines are a family of small proteins known for their ability to control cell migration in the body. Their receptors belong to the class A subfamily of G protein-coupled receptors. In recent years, chemokines have grown in importance, because they are involved in inflammation and autoimmune disease. Some of them are also involved in infectious disease, since two chemokine receptors, CXCR4 and CCR5, are used by the human immunodeficiency virus (HIV) to gain entry to cells. Several years ago it also became clear that chemokines can also influence tumor cells. Specifically, tumor cells express chemokine receptors in a nonrandom manner, and this suggested a role for chemokines in the metastatic destination of tumor cells. By far the most common chemokine receptor expressed by many cancer cells is CXCR4. Its ligand, CXCL12, is strongly expressed in lung, liver, bone marrow and lymph nodes, places that represent common metastatic destinations in many cancers. Many studies have now validated the concept that chemokines and their receptors influence metastasis. The potential therapeutic importance of these observations depends on the role that each metastatic destination such as liver, lung, bone marrow, etc., plays in the prog...Continue Reading

Citations

Aug 25, 2007·Cancer Metastasis Reviews·Simi Ali, Gwendal Lazennec
Oct 24, 2007·Molecular Neurobiology·A H de HaasK P H Biber
Jul 7, 2011·The Journal of Biological Chemistry·Fabien M DécaillotPallavi Sachdev
May 13, 2010·Molecular Cancer Research : MCR·Maria V BarbolinaM Sharon Stack
Jun 16, 2011·Molecular Cancer·Brian A ZabelThomas J Schall
Feb 26, 2011·Journal of Translational Medicine·Claudia RubieMartin K Schilling
Apr 14, 2010·PloS One·Barbara IngoldChristoph Röcken
Apr 10, 2012·PloS One·Zhongxing LiangHyunsuk Shim
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Rajesh SinghShailesh Singh
Jan 17, 2013·International Journal of Molecular Sciences·Sebastiano Cavallaro
Jan 7, 2009·Journal of Cancer Research and Clinical Oncology·Juliana Laino do Val CarneiroMaria Angelica Ehara Watanabe
Aug 21, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kee Hwan KwonYoung Gyu Eun
Feb 20, 2007·Molecular Aspects of Medicine·Luca PersanoStefano Indraccolo
Jun 27, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Syed A KhurramSimon A Whawell
Dec 22, 2016·International Journal of Molecular Sciences·Hui-Yun PengDian Gao
Jul 22, 2018·European Journal of Immunology·Mario GrünbergHans-Jürgen Mägert
Jan 10, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yuanqiang LinHui Wang
Dec 16, 2006·Cancer Metastasis Reviews·Vladislav V Glinsky
Sep 12, 2007·Journal of Neuroscience Research·Italo MocchettiEliezer Masliah
Sep 25, 2007·Clinical & Experimental Metastasis·Adit Ben-Baruch
Oct 31, 2008·Scandinavian Journal of Immunology·C RubieM K Schilling
Jan 13, 2009·Cell Death and Differentiation·M KochetkovaS R McColl
Nov 17, 2009·Histopathology·Barbara IngoldChristoph Röcken
Jul 3, 2010·Pathology International·Bungo FurusatoJohng S Rhim
Sep 9, 2010·Cell and Tissue Research·Wen-Cheng ChenYing-Chieh Tsai
Aug 6, 2009·British Journal of Cancer·P A HavreN H Dang
Apr 7, 2011·Journal of Cancer Research and Clinical Oncology·Carl C SchimanskiMartin R Berger
Jun 3, 2015·Biology of the Cell·Kinga G BlecharzPeter Vajkoczy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Related Papers

International Journal of Cancer. Journal International Du Cancer
A Zlotnik
Cancer Immunology, Immunotherapy : CII
Alessandro OttaianoStefania Scala
© 2022 Meta ULC. All rights reserved