Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behçet's disease

Arthritis and Rheumatism
M Ben AhmedH Louzir

Abstract

To investigate a possible pathogenic role of cytokines in Behçet's disease (BD) by focusing on the analysis of cytokine gene expression within mucocutaneous BD lesions. The study group comprised 20 patients with active BD. In this group, a set of chemokines as well as Th1 and Th2 cytokines in biopsy specimens obtained from oral and genital ulcers, pseudofolliculitis lesions, and lesions at the site of pathergy testing were studied using real-time quantitative reverse transcriptase-polymerase chain reaction. We observed important increases in the expression of interleukin-8 (IL-8) ( approximately 700-fold), monocyte chemoattractant protein 1 ( approximately 65-fold), interferon-gamma ( approximately 71-fold), and IL-12 ( approximately 69-fold) messenger RNA in BD lesions compared with normal skin. Except for IL-10 ( approximately 75-fold increase), Th2 cytokines (i.e., IL-4 and IL-13) were absent. Our data suggest a direct role of Th1 lymphocytes in the pathogenesis of mucocutaneous BD lesions.

References

Mar 1, 1996·Journal of Dermatological Science·Y YamakawaH Nakajima
Oct 1, 1996·Genome Research·C A HeidP M Williams
Sep 10, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·F GerosaG Trinchieri
Oct 17, 2001·Annals of the Rheumatic Diseases·H Direskeneli

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Citations

Jun 16, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U PleyerN Stübiger
Apr 5, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ali YalçındağF Nilüfer Yalçındağ
May 25, 2010·Clinical Rheumatology·Violetta D KapsimaliPhaedon G Kaklamanis
Jan 4, 2008·Clinical Reviews in Allergy & Immunology·Melike MelikogluHasan Yazici
May 7, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Z-Hye LeeErnest S Chiu
Jun 26, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Camila B GalloNorberto N Sugaya
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Hasan YaziciSebahattin Yurdakul
Oct 9, 2012·Annals of the Rheumatic Diseases·Yun Jong LeeEun Bong Lee
Nov 15, 2005·The Journal of Clinical Investigation·Bing MaJack A Elias
May 13, 2010·Arthritis Research & Therapy·Yukie YamaguchiMasataka Kuwana
Nov 26, 2013·Human Immunology·Ziyan WuYongzhe Li
Nov 12, 2013·La Revue de médecine interne·M H Houman, N Bel Feki
Jun 5, 2007·La Presse médicale·Mohamed Habib HoumanKamel Hamzaoui
Apr 15, 2014·Rheumatology International·Seyedeh Tahereh FaeziFereydoun Davatchi
Feb 7, 2014·Modern Rheumatology·Esin Aktas CetinGunnur Deniz
Dec 27, 2013·Immunopharmacology and Immunotoxicology·Zineb DjerabaChafia Touil-Boukoffa
Jul 1, 2005·Expert Opinion on Therapeutic Patents·Deric de Wit, Susan Lightman
Aug 19, 2014·Journal of Clinical Laboratory Analysis·Zeynep Meltem AkkurtMustafa Arica
Dec 3, 2014·Clinical and Experimental Medicine·Gianluigi MazzoccoliAngelo De Cata
Sep 1, 2011·The Journal of Allergy and Clinical Immunology·Haner DireskeneliCezmi A Akdis
Oct 31, 2009·La Revue de médecine interne·F Otmani
Feb 27, 2007·Human Immunology·Graham R WallaceMiles R Stanford
May 13, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andy SunChun-Pin Chiang
Jan 30, 2007·Tissue Antigens·E B LeeY W Song
Mar 2, 2012·Arthritis and Rheumatism·Joana M XavierSofia A Oliveira
Mar 23, 2011·International Journal of Immunogenetics·A A OzçimenH B Oral
Dec 12, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S ChoD Bang
Apr 9, 2014·International Journal of Rheumatic Diseases·Mafalda MatosSofia A Oliveira
May 23, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ioannis Kalampokis, C Egla Rabinovich
Oct 24, 2006·Human Immunology·Yun Jong LeeYeong Wook Song
Aug 29, 2006·American Journal of Ophthalmology·Jae Kyoun AhnYeoung Geol Park
Jul 11, 2006·La Revue de médecine interne·Z AmouraJ-C Piette

❮ Previous
Next ❯

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