Involvement of cholecystokinin in baseline and post-prandial whole body insulin sensitivity in rats

European Journal of Pharmacology
Barna PeitlZoltan Szilvassy

Abstract

The objective of the study was to investigate the role of cholecystokinin (CCK) on the food-induced insulin sensitization phenomenon in healthy Long Evans Tokushima Otsuka (LETO) and Otsuka Long Evans Tokushima Fatty (OLETF) rats. Whole body insulin sensitivity determined by hyperinsulinaemic euglycaemic glucose clamping and the rapid insulin sensitivity test served as endpoints. Determinations were done in both fasted and re-fed animals. The involvement of CCK in post-prandial insulin sensitization was assessed by using proglumide, a CCK receptor blocker, by assessment of hypothalamic CCK-1/CCK-2 receptor expression by rt-PCR technique and by plasma insulin immunoreactivity determinations by means of radioimmunoassay as pharmacological, genetic and analytical approaches, respectively. The body weight of the OLETF rats and the amount of food consumed much exceeded those seen with LETO rats. The post-prandial increase in insulin sensitivity was marked in LETO, but not in OLETF rats. Intravenous proglumide attenuated post-prandial insulin sensitivity in LETO rats, with no effect in OLETF rats. Nevertheless, baseline insulin sensitivity was much lower in OLETF than in LETO rats. Treatment with rosiglitazone increased baseline insu...Continue Reading

References

Jun 1, 1988·The Journal of Clinical Investigation·R A LiddleA R McDonald
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
May 25, 1995·Biochemical and Biophysical Research Communications·A FunakoshiA Kono
Oct 1, 1994·Diabetes Research and Clinical Practice·K KawanoT Natori
Jan 1, 1994·Peptides·J N Crawley, R L Corwin
May 18, 1999·Canadian Journal of Physiology and Pharmacology·W W LauttM P Macedo
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Mary Courtney MooreAlan D Cherrington
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 2, 2002·Autonomic Neuroscience : Basic & Clinical·Martin G Latour, W Wayne Lautt
Jun 5, 2002·European Journal of Pharmacology·Robert PorszaszZoltan Szilvassy
Jul 9, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·T M Wallace, D R Matthews
Jun 6, 2003·Medicinal Research Reviews·Rosario Herranz
Dec 6, 2003·Pediatric Diabetes·Wayne S CutfieldPaul L Hofman
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Timothy H Moran, Kimberly P Kinzig
May 7, 2005·Metabolism: Clinical and Experimental·Barna PeitlZoltán Szilvássy
Jan 28, 2006·European Journal of Pharmacology·Judit SzilvássyZoltán Szilvássy
Aug 8, 2006·Gastroenterology·Michael Camilleri
Sep 7, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Barna PeitlZoltán Szilvássy
May 25, 2007·European Journal of Pharmacology·László HerczegBarna Peitl
Jun 16, 2007·Metabolism: Clinical and Experimental·Barna Peitl, Zoltán Szilvássy
Jun 22, 2007·Physiology & Behavior·Erik Näslund, Per M Hellström
Jan 15, 2008·Physiology & Behavior·Timothy H Moran
Feb 17, 2009·Metabolism: Clinical and Experimental·Barna PeitlZoltán Szilvássy
Mar 17, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·F C J Starrenburg, J P A M Bogers
Apr 7, 2009·Regulatory Peptides·Graham J Dockray
May 8, 2009·Physiology & Behavior·Graham J Dockray

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Citations

Sep 17, 2013·Drug Design, Development and Therapy·Diána KovácsBarna Peitl
Jan 1, 2014·Journal of Clinical Medicine·W Wayne Lautt, Hui Helen Wang
Jun 16, 2016·Cephalalgia : an International Journal of Headache·Balázs MaricsMária Dux
Jul 19, 2011·Journal of Cardiovascular Pharmacology·Agnes BajzaZoltán Szilvássy

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