Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response

Pain
Isela E Juárez-RojopJorge E Torres-López

Abstract

The possible pronociceptive role of peripheral cholecystokinin (CCK-8) as well as CCK(A) and CCK(B) receptors in diabetic rats was assessed. Subcutaneous injection of 0.5% formalin induced a greater nociceptive behavior in diabetic than in non-diabetic rats. Moreover, local peripheral injection of CCK-8 (0.1-100 microg) significantly increased 0.5% formalin-induced nociceptive activity in diabetic, but not in non-diabetic, rats. This effect was restricted to the formalin-injected paw as administration of CCK-8 into the contralateral paw was ineffective. Local peripheral administration of CCK-8, in the absence of formalin injection, produced a low level of, but significant increase in, flinching behavior in diabetic compared to non-diabetic rats. In addition, local peripheral administration of the non-selective CCK receptor antagonist proglumide (1-100 microg), CCK(A) receptor antagonist lorglumide (0.1-100 microg) or CCK(B) receptor antagonist CR-2945 (0.1-100 microg), but not vehicle or contralateral administration of CCK receptor antagonists, significantly reduced 0.5% formalin-induced flinching in diabetic rats. CR-2945 was the most effective drug in this condition. These effects were not observed in non-diabetic rats. The l...Continue Reading

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Citations

Sep 10, 2013·Life Sciences·Geovanna Nallely Quiñonez-BastidasVinicio Granados-Soto
May 10, 2011·European Journal of Pharmacology·Deysi Y Bermúdez-OcañaIsela Esther Juárez-Rojop
Jul 3, 2008·European Journal of Pharmacology·Guillermina Yanek Jiménez-AndradeVinicio Granados-Soto
Oct 9, 2007·European Journal of Pharmacology·Rosaura Arreola-EspinoVinicio Granados-Soto
Nov 25, 2014·Drug Development Research·Angel Zúñiga-RomeroLuis Fernando Ortega-Varela
May 3, 2015·Pharmacological Reports : PR·Isela E Juárez-RojopVinicio Granados-Soto
Feb 22, 2011·Pharmacology, Biochemistry, and Behavior·Mónica Ambriz-TututiVinicio Granados-Soto
Apr 4, 2017·Drug Development Research·Samuel Suarez-MendezIsela Esther Juárez-Rojop
Jul 12, 2007·Chemical Reviews·Jade S BlakeneyDavid P Fairlie

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