Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway.

Journal of Molecular and Cellular Cardiology
Guanghong JiaDevendra K Agrawal

Abstract

Proliferation and migration of vascular smooth muscle cells (VSMCs) lead to intimal thickening and influence the long-term patency of venous graft post coronary arterial bypass graft. There is increasing evidence that connexins are involved in the development of intimal hyperplasia and restenosis. We assessed connexin 43 (Cx43) expression and its role in angiotensin II-induced proliferation and migration of smooth muscle cells and the signal pathways involved in human saphenous vein bypass conduits. Angiotensin II significantly increased gap junctional intercellular communication and induced the expression of Cx43 in human saphenous vein SMCs in a dose- and time-dependent manner through angiotensin II type 1 receptor. The effect of angiotensin II was blocked by siRNA of ERK 1/2, p38 MAPK and JNK, respectively. Overexpression of Cx43 markedly increased the proliferation of saphenous vein SMCs. However, siRNA for Cx43 inhibited angiotensin II-induced proliferation, cyclin E expression and migration of human saphenous vein SMCs. In dual-luciferase reporter assay, angiotensin II markedly activated AP-1 transcription factor, which was significantly attenuated by a dominant-negative AP-1 (A-Fos) with subsequent inhibition of angioten...Continue Reading

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Citations

May 18, 2011·BMC Cell Biology·Chi-Young WangHung-I Yeh
Sep 5, 2013·Molecular and Cellular Biochemistry·Xianghong WuLaval Andy Alain
Feb 2, 2016·International Journal of Cardiology·Xiao-Wen WangZhi-Qian Lu
Aug 31, 2010·Biochimica Et Biophysica Acta·Mathieu VinkenVera Rogiers
Aug 25, 2010·Journal of Cellular and Molecular Medicine·Guanghong JiaDevendra K Agrawal
Dec 14, 2011·Biochimica Et Biophysica Acta·Petra KameritschUlrich Pohl
Sep 24, 2015·PloS One·Alban LongchampJacques-Antoine Haefliger
Apr 28, 2017·Cardiovascular Research·Florent AllagnatJacques-Antoine Haefliger
Aug 15, 2012·Pancreas·Atsushi MasamuneTooru Shimosegawa
Jun 12, 2008·Journal of Cellular and Molecular Medicine·Guanghong JiaDevendra K Agrawal
Jan 10, 2019·Plastic and Reconstructive Surgery·Dominic HennUlrich Kneser
Jul 2, 2017·Journal of the American Society of Nephrology : JASN·Panagiotis KavvadasChristos E Chadjichristos
Sep 13, 2012·Cardiology in Review·Francis Y KimDavid J Whellan
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Apr 6, 2013·International Journal of Cancer. Journal International Du Cancer·Wen-Wei ChangChe-Hsin Lee
Jul 17, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Guanghong JiaDevendra K Agrawal

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