Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation

PloS One
Chao BianNing Lü

Abstract

The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord. Accumulating evidence has showed the contribution of spinal microglia to spinal LTP and pathological pain. As a key signaling of neurons-microglia interactions, the involvement of CX3CL1/CX3CR1 signaling in pathological pain has also been investigated extensively. The present study examined whether CX3CL1/CX3CR1 signaling plays a role in spinal LTP. The results showed that 10-trains tetanic stimulation (100 Hz, 2s) of the sciatic nerve (TSS) produced a significant LTP of C-fiber-evoked field potentials lasting for over 3 h in the rat spinal dorsal horn. Blockade of CX3CL1/CX3CR1 signaling with an anti-CX3CR1 neutralizing antibody (CX3CR1 AB) markedly suppressed TSS-induced LTP. Exogenous CX3CL1 significantly potentiated 3-trains TSS-induced LTP in rats. Consistently, spinal LTP of C-fiber-evoked field potentials was also induced by TSS (100 Hz, 1s, 4 trains) in all C57BL/6 wild type (WT) mice. However, in CX3CR1-/- mice, TSS failed to induce LTP and behavioral hypersensitivity, confirming an essential role of CX3CR1 in spinal LTP induction. Furthermore, blockade of IL-1...Continue Reading

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Citations

Apr 9, 2017·Cellular and Molecular Life Sciences : CMLS·Zhi-Jun ZhangYong-Jing Gao
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
May 30, 2019·Journal of Neuroinflammation·Sergio M BorghiWaldiceu A Verri
Dec 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Wen-Jing DaiNing Lü

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