Involvement of CXCR4 in Normal and Abnormal Development

Cells
Nanako KawaguchiToshio Nakanishi

Abstract

CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor (SDF), also known as CXC motif ligand (CXCL) 12. Through the SDF-1/CXCR4 axis, both homing and migration of hematopoietic (stem) cells are regulated through niches in the bone marrow. Outside of the bone marrow, however, SDF-1 can recruit CXCR4-positive cells from the bone marrow. SDF/CXCR4 has been implicated in the maintenance and/or differentiation of stemness, and tissue-derived stem cells can be associated with SDF-1 and CXCR4 activity. CXCR4 plays a role in multiple pathways involved in carcinogenesis and other pathologies. Here, we summarize reports detailing the functions of CXCR4. We address the molecular signature of CXCR4 and how this molecule and cells expressing it are involved in either normal (maintaining stemness or inducing differentiation) or abnormal (developing cancer and other pathologies) events. As a constituent of stem cells, the SDF-1/CXCR4 axis influences downstream signal transduction and the cell microenvironment.

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Citations

Jan 7, 2020·Expert Opinion on Drug Metabolism & Toxicology·Miao MiaoGuangdi Li
Jun 12, 2020·Physiological Reports·Gurpreet Kaur AulakhJaswant Singh
Sep 11, 2020·Cardiovascular Drugs and Therapy·Suman DalalKrishna Singh
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Feb 14, 2021·Stem Cell Research & Therapy·Rosario Hervás-SalcedoRosa María Yañez
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Feb 20, 2021·Cancer Biology & Therapy·Eric T AlexanderSusan K Gilmour
Mar 17, 2021·Disease Models & Mechanisms·Beverly A KarpinskiAnthony-Samuel LaMantia
May 5, 2021·Journal of Translational Medicine·Andrea GilgJan Münch
May 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Giulia BertoliniLuca Roz
Aug 12, 2021·Disease Models & Mechanisms·Beverly A KarpinskiAnthony-Samuel LaMantia

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Methods Mentioned

BETA
co-immunoprecipitation

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