Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats

British Journal of Pharmacology
Michael SalmonK F Chung


Airway smooth muscle thickening is a characteristic feature of airway wall remodelling in chronic asthma. We have investigated the role of the leukotrienes in airway smooth muscle (ASM) and epithelial cell DNA synthesis and ASM thickening following repeated allergen exposure in Brown Norway rats sensitized to ovalbumin. There was a 3 fold increase in ASM cell DNA synthesis, as measured by percentage bromodeoxyuridine (BrdU) incorporation, in repeatedly ovalbumin-exposed (4.1%, 3.6-4.6; mean, 95% c.i.) compared to chronically saline-exposed rats (1.3%, 0.6-2.1; P<0.001). Treatment with a 5-lipoxygenase enzyme inhibitor (SB 210661, 10 mg kg(-1), p.o.) and a specific cysteinyl leukotriene (CysLT1) receptor antagonist, pranlukast (SB 205312, 30 mg kg(-1), p.o.), both attenuated ASM cell DNA synthesis. Treatment with a specific leukotriene B4 (BLT) receptor antagonist (SB 201146, 15 mg kg(-1), p.o.) had no effect. There was also a significant, 2 fold increase in the number of epithelial cells incorporating BrdU per unit length of basement membrane after repeated allergen exposure. This response was not inhibited by treatment with SB 210661, pranlukast or SB 201146. A significant increase in ASM thickness was identified following rep...Continue Reading


Aug 1, 1991·The American Review of Respiratory Disease·S SapienzaJ G Martin
Mar 11, 1989·Lancet·W R RocheS T Holgate
Jul 1, 1989·The Journal of Allergy and Clinical Immunology·A J WardlawA B Kay
Oct 1, 1987·The American Review of Respiratory Disease·S A SilbaughS R Baker
Aug 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·X Y HuaP Hedqvist
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·S LamH Salari
Mar 1, 1987·Clinical Allergy·H Bisgaard, M Pedersen
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Dec 4, 1980·Nature·S E DahlénB Samuelsson
Mar 1, 1994·American Journal of Respiratory Cell and Molecular Biology·M K GlassbergD Puett
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·R A PanettieriR K Murray
Nov 3, 1994·European Journal of Pharmacology·S R TudhopeP J Gardiner
Feb 1, 1994·British Journal of Pharmacology·P R TomlinsonA G Stewart
Feb 1, 1994·Journal of Leukocyte Biology·C S SpadaD F Woodward
Aug 1, 1993·The American Review of Respiratory Disease·C G WangJ G Martin
Mar 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H FujiwaraT Takeda
Jan 1, 1993·The American Review of Respiratory Disease·J G MartinW S Powell
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·Z DiamantP J Sterk

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