PMID: 9556025Apr 29, 1998Paper

Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives

Journal of Neuroscience Research
B Zhao, J P Schwartz

Abstract

Cytokines have been recognized to play an important role both in normal development of the brain, when they act as neurotrophic factors, as well as following injury. While both the cytokines and their receptors are synthesized and expressed in the brain normally (albeit at low levels), it has become clear that elevated levels are associated with many neurological disorders. In this review, we have chosen to present the data for only a few of the cytokines, including interleukin-1beta, interleukin-3, interleukin-6, interferon-gamma, transforming growth factor-beta, and tumor necrosis factor-alpha. Data are presented that suggest roles they may play in human disorders, including stroke, multiple sclerosis, Alzheimer's disease, and several psychiatric disorders. The results in human disease are compared with results obtained in a variety of transgenic animal models. The mouse models have very different disorders depending on whether a cytokine is overexpressed either peripherally or in either astrocytes or neurons. The potential significance of this to the understanding of human disease is discussed.

Citations

Nov 28, 2013·Scientifica·Carlos Barcia
Oct 22, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Sonja EntringerPathik D Wadhwa
Nov 3, 2010·Journal of Neuroinflammation·An-Gaëlle CeulemansYvette Michotte
Aug 2, 2011·Journal of Neuroinflammation·Ingo SchulzHans-Ulrich Demuth
Jan 23, 2016·International Journal of Experimental Pathology·Julio César Rojas-CastañedaMarcela Arteaga-Silva
Jan 7, 2015·Pharmacology & Therapeutics·Sonali ReisingerDaniela D Pollak
Mar 27, 2012·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Milan FialaMartin Weinand
Apr 12, 2001·Cytokine·K M Kulmatycki, F Jamali
Feb 18, 2011·International Journal of Experimental Pathology·Julio César Rojas-CastañedaCamilo Ríos
Mar 12, 2005·Journal of the Neurological Sciences·Andrius Baskys, Morten Blaabjerg
Apr 6, 2004·Progress in Neurobiology·Kazuhiro TakumaToshio Matsuda
Jun 22, 2005·Brain & Development·Hasan TekgulSarenur Gokben
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Urs MeyerBenjamin K Yee
Jan 9, 2003·Clinics in Perinatology·Rodney E Willoughby, Karin B Nelson
Dec 3, 2014·Neuropharmacology·Donna L Gruol

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