Involvement of D1 dopamine receptor in MDMA-induced locomotor activity and striatal gene expression in mice

Brain Research
Nadia BenturquiaCynthia Marie-Claire

Abstract

3,4-Methylenedioxymethamphetamine (MDMA), a widely used recreational drug with psychoactive properties, induces both serotonin and dopamine release in the brain. In rats and mice MDMA induces behavioural changes and has rewarding effects but little is known about its cellular effects. We have previously shown that the ERK pathway is important for the changes in gene expression observed in mice striatum after treatment with this psychostimulant. In this study we investigated the role of D1 receptors in MDMA-induced locomotor hyperactivity and regulation of immediate-early genes (Fos, Fosb, Egr1 and Egr2) mRNA levels requiring ERK activity in mice striatum. We used the selective D1 receptor antagonist, SCH23390 at a dose (0.05 mg/kg) that did not influence locomotor activity. This dose totally blocked MDMA-induced locomotor activity but only partially the increase in transcription levels of Fos, Fosb, Egr1 and Egr2 (24%, 23%, 22% and 29% respectively). In conclusion, our results showed that D1 receptors play a key role in the acute MDMA-induced hyperlocomotion and that ERK pathway is partially under D1 receptors control to induce Fos, FosB, Egr1 and Egr2 transcription.

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Citations

Apr 30, 2013·European Journal of Pharmacology·Emilie BelkaïCynthia Marie-Claire
Apr 28, 2011·Behavioural Pharmacology·Adam StewartAllan V Kalueff
Jun 21, 2011·Neurotoxicology and Teratology·Russell RiehlAllan V Kalueff
Mar 25, 2014·British Journal of Pharmacology·A R GreenK C F Fone
Sep 23, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Konstantin Kuteykin-Teplyakov, Rafael Maldonado
Sep 26, 2012·Advances in Pharmacological Sciences·Naila Rasheed, Abdullah Alghasham
Sep 29, 2011·European Journal of Pharmacology·Yoriko Akimoto, Mitsuhiro Furuse
Feb 18, 2015·PloS One·Sara CapocciaFrancesca Cirulli
Nov 26, 2016·Drug and Chemical Toxicology·Seyed Reza Fatemi TabatabaieMohammad Reza Tabandeh
Sep 27, 2012·Journal of Biological Rhythms·Yuan-Yuan LiuZhi-Li Huang
Nov 13, 2010·Human & Experimental Toxicology·T A AlvarengaM L Andersen
Feb 23, 2020·Brain Research·Jessica Mead, Andrew Parrott

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