Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV

Peptides
J J Braszko

Abstract

An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passive avoidance (PA) task, and improves object recognition (OR) in rats. Since the dopaminergic system is crucial for the cognitive processes, in this study our aim was to determine the dopaminergic D1 mediation of these effects using SCH 23390 as a selective D1 receptor antagonist. Male Wistar rats (180-200 g), pretreated with SCH 23390 (R-[+]-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) 0.05 mg/kg intraperitoneally (IP), were given Ang IV or des-Phe6-Ang IV (1 nmol ICV) 1 h later and then tested in the above cognitive paradigms, as well as in the open field and an elevated 'plus' maze to control for the unspecific, respectively, motor and emotional, effects of our treatments. Both, Ang IV and des-Phe6-Ang IV effectively enhanced learning of CARs (P < 0.05), recall of PA (P < 0.001), and improved OR (P < 0.001). Pretreatment with SCH 23390 abolished the cognitive effects of both peptides....Continue Reading

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Citations

Oct 24, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Adam Holownia, Jan J Braszko
Aug 15, 2012·Psychopharmacology·Jan Józef BraszkoPiotr Jakubów
Jan 6, 2009·BMC Neuroscience·Siew Yeen ChaiAnthony L Albiston
Jan 6, 2009·BMC Neuroscience·Paul R Gard
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht
Nov 24, 2005·Clinical and Experimental Hypertension : CHE·Jan J Braszko
Apr 19, 2011·Behavioural Brain Research·Bettina ClausenGert R J Christoffersen
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Jan 1, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jan J Braszko
Oct 7, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jan J Braszko
Dec 2, 2008·CNS Neuroscience & Therapeutics·Dimitri De BundelYvette Michotte
Jun 24, 2011·Mass Spectrometry Reviews·Theodora KatsilaConstantin Tamvakopoulos
Feb 19, 2013·Neuropharmacology·Jason J ParisJay P McLaughlin
Nov 10, 2011·Neurobiology of Learning and Memory·Thiago L N LazaroniGrace S Pereira
Nov 10, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jan Jozef BraszkoPrzemyslaw Wielgat
Aug 11, 2007·Journal of Separation Science·Katrien LanckmansYvette Michotte
Jul 20, 2007·American Journal of Physiology. Renal Physiology·Kumar KotloRobert S Danziger
Oct 2, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Paul R GardPaula Tran

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