Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease

Advances in Experimental Medicine and Biology
Francisco LeonBrian L Kelsall

Abstract

In conclusion, during inflammation, DCs are likely activated by inflammatory signals and induced to migrate to T cell zones of organized lymphoid tissues where the cells induce T cell responses. In addition to their established role in T cell priming and the induction of tolerance, DCs may act to enhance (or possibly suppress) T cell responses at sites of mucosal inflammation. Determining the importance of DCs in this regard, as well as establishing a potential role for DCs in continuous activation of naive or central memory cells in lymph nodes draining inflammatory sites, will elucidate the role of DCs as a potential therapeutic target for chronic inflammatory diseases, like IBD. Resident intestinal macrophages are noninflammatory and do not efficiently present antigens to intestinal T cells, yet are avidly phagocytic and able to kill internalized organisms. During intestinal inflammation, monocytes are recruited from the blood, become inflammatory macrophages in the inflamed tissue, and are major contributors to tissue destruction and perpetuation of inflammation via their production of chemokines and pro-inflammatory cytokines. Macrophages may also contribute directly to DC activation and maturation, which would drive DCs t...Continue Reading

Citations

Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan UngaroMaria T Abreu
Jul 31, 2008·World Journal of Gastroenterology : WJG·Fausto Sanchez-MunozJesus-K Yamamoto-Furusho
Oct 13, 2011·ISRN Gastroenterology·Alejandra de Moreno de LeblancJean Guy Leblanc
Oct 3, 2008·Scandinavian Journal of Gastroenterology·Yoshiyuki MishimaYoshikazu Kinoshita
Aug 2, 2017·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzalez
Jan 26, 2016·Journal of Dairy Science·J R KanwarG W Krissansen
May 9, 2007·Digestive Diseases and Sciences·Raul A WapnirIvana Vancurova
Apr 12, 2013·Periodontology 2000·Jeffrey L EbersoleOctavio A Gonzaléz
Jul 3, 2007·Inflammatory Bowel Diseases·Alessandra GamberoJosé Pedrazzoli

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