PMID: 8968027Dec 1, 1996Paper

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain

Bone
S C F RawlinsonL E Lanyon

Abstract

The involvement of functional ion channels in previously documented early responses of osteocytes and osteoblasts to mechanical strain in bone tissue was investigated in explants of rat ulnae by the use of ion channel blockers. Gadolinium chloride (a blocker of stretch/shear-sensitive cation channels) elevated basal prostaglandin (PG) E2 and prostacyclin (PGI2) release and osteocyte glucose-6-phosphate dehydrogenase (G6PD) activity, but was associated with a reduction in basal nitric oxide (NO) production. Gadolinium abolished loading-related increases in the release of PGI2 and NO and osteocyte G6PD activity. Gadolinium also reduced the loading-related release of PGE2 assumed to originate from osteoblasts and the magnitude of loading-related increases in G6PD activity in these cells. Nifedipine (a blocker of L-type voltage-dependent calcium channels) had no effect on basal levels of prostanoid or NO release, or G6PD activity in osteocytes or osteoblasts, and did not affect loading-related release of PGI2 or increase in osteocyte G6PD. However, nifedipine prevented loading-related increases in PGE2 and NO release and osteoblast G6PD activity. These results are consistent with osteocytes' response to bone loading requiring activ...Continue Reading

References

Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D L YpeyP J Nijweide
Apr 1, 1992·The American Journal of Physiology·M J DavisJ D Hood
Aug 1, 1990·Pflügers Archiv : European journal of physiology·R M DavidsonA L Auerbach
Dec 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C RawlinsonL E Lanyon
Sep 1, 1991·The American Journal of Physiology·K M Reich, J A Frangos
Apr 1, 1990·Journal of Cellular Physiology·K M ReichJ A Frangos
Sep 1, 1990·The American Journal of Physiology·B A Biagi, J J Enyeart
Jan 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M W OtterG V Cochran
Jul 1, 1990·Calcified Tissue International·D W Murray, N Rushton
Jul 1, 1989·Calcified Tissue International·M J Pead, L E Lanyon
Oct 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T M SkerryL E Lanyon
Apr 1, 1987·Food Additives and Contaminants·C L WaltersP L Smith
Jul 1, 1985·Calcified Tissue International·C T Rubin, L E Lanyon
Jan 3, 1980·Biochimica Et Biophysica Acta·D SomjenA Harell
Mar 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S L DallasL E Lanyon
Jan 27, 1995·Cell·D E Clapham
Mar 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Klein-NulendE H Burger
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C H TurnerM W Otter
Jun 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Z ChengL E Lanyon
Feb 1, 1993·Bone and Mineral·T J ChambersJ W Chow
Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A A PitsillidesL E Lanyon
Aug 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C RawlinsonL E Lanyon

❮ Previous
Next ❯

Citations

Jun 30, 2005·Journal of Bone and Mineral Metabolism·Charles H Turner, Alexander G Robling
Sep 17, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Peter AugatLutz Claes
Apr 1, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D D Bikle
Jul 30, 2009·Odontology·Lisa R AmirAntonius L J J Bronckers
Jan 20, 2004·Experimental Eye Research·Wei CuiPeter J McDonnell
Mar 11, 2000·Biomaterials·K Anselme
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B FermorF Guilak
Apr 2, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Adam H HsiehK L Paul Sung
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·S Nomura, T Takano-Yamamoto
Jan 5, 2010·Nature Reviews. Rheumatology·Engin OzciviciClinton T Rubin
Feb 23, 2011·Tissue Engineering. Part B, Reviews·Josephine C BodleElizabeth G Loboa
Apr 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhousheng XiaoL Darryl Quarles
Feb 8, 2006·Plastic and Reconstructive Surgery·Morad AskariJames P Bradley
Jul 13, 2006·Annual Review of Biomedical Engineering·Alexander G RoblingCharles H Turner
Feb 2, 2013·Stem Cell Research & Therapy·Ben P HungWarren L Grayson
Dec 28, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Damian C GenetosRandall L Duncan
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K SakaiY Iwamoto
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G ZamanL E Lanyon
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D M SalterM O Wright
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M IkegameH Kawashima
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K D Ryder, R L Duncan
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jiliang LiCharles H Turner
Oct 13, 2009·Critical Reviews in Eukaryotic Gene Expression·Alexander G Robling, Charles H Turner
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Elise F MorganKristy T Salisbury Palomares
Jun 13, 2001·Biochemical and Biophysical Research Communications·Y GuS J Publicover
Feb 1, 2000·Biochemical and Biophysical Research Communications·K NaruseM Itoman
Sep 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yilin WangSheldon Weinbaum
Oct 3, 1999·Medical & Biological Engineering & Computing·A J el HajS J Publicover
Feb 15, 2003·FEBS Letters·Theodora E DanciuPeter V Hauschka
May 12, 2012·Gene·William R ThompsonJanet Rubin
Sep 28, 1998·The American Journal of the Medical Sciences·S C Cowin, S Weinbaum
Feb 24, 2012·Journal of Biomechanics·William S Van DykeOzan Akkus
Nov 26, 2009·Ageing Research Reviews·Miaozong WuEric R Blough
Oct 13, 2009·Journal of Biomechanics·Jan-Hung ChenCraig A Simmons
Feb 19, 2008·Bone·Lynda F Bonewald, Mark L Johnson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.