PMID: 7539054Jun 1, 1995Paper

Involvement of different types of voltage-sensitive calcium channels in the presynaptic regulation of noradrenaline release in rat brain cortex and hippocampus

Journal of Neurochemistry
J SabriáA Badia

Abstract

Transmitter release at the nerve terminal is mediated by the influx of Ca2+ through voltage-sensitive calcium channels (VSCCs). Many types of VSCCs have been found in neurons (T, N, L, and P), but uncertainty remains about which ones are involved in neuronal excitation-secretion coupling. Specific ligands for the L- and N-type VSCCs were used to determine which of these subtypes might be involved in the K(+)-evoked [3H]noradrenaline release from superfused rat brain cortical and hippocampal synaptosomes. In cortical presynaptic terminals the 1,4-dihydropyridine agonist Bay K8644 enhanced the K+ (15 mM)-evoked [3H]noradrenaline release. This effect was reversed by the 1,4-dihydropyridine antagonists nimodipine and nitrendipine. The L-type VSCC ligands had no effect on hippocampal synaptosomes. In contrast, the N-type VSCC blocker omega-conotoxin markedly reduced the K(+)-evoked [3H]noradrenaline release in nerve terminals from both regions. Inhibition was greater in hippocampal synaptosomes. When applied together the inhibitory actions of nimodipine and omega-conotoxin were approximately additive. These findings indicate that both L- and N-type VSCCs participate in noradrenaline release in rat brain cortex and suggest that norad...Continue Reading

Citations

Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Jul 1, 1996·Psychopharmacology·H C Jackson, M A Scheideler
Jul 1, 2009·Journal of Neuroscience Research·Jose A Morales-GarciaAna Perez-Castillo
Sep 26, 2008·Journal of Neurophysiology·Evan S HillPaul S Katz
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ai-Qun HuPing Zheng
Jun 18, 2002·European Journal of Pharmacology·Robert MellerTrevor Sharp
Dec 25, 2002·Progress in Neurobiology·Luca RaiteriGiambattista Bonanno
May 18, 2001·Brain Research. Brain Research Protocols·A Garcia-SanzM V Clos

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