Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas

Clinical Neurology and Neurosurgery
G NagashimaK Hirakawa

Abstract

We investigated the expression of c-myc and c-sis/PDGF mRNA and protein products in 20 cases of meningiomas of various grades: 10 benign, 5 atypical and 5 anaplastic meningiomas. All cases of atypical and anaplastic meningiomas were positive for c-myc protein and mRNA by immunohistochemistry and in situ hybridisation, respectively, while all 10 benign meningiomas were negative for c-myc immunostaining, with only one benign tumour positive for c-myc mRNA. Expression of PDGF-BB protein and c-sis mRNA were seen in more than 80% of the meningioma cases and was not restricted to the histological grades of meningiomas. Semiquantitative analysis showed that the frequency of c-myc immunopositive cells positively correlated with Ki-67 proliferative indices. Our findings suggest that c-myc, but not c-sis/PDGF, has some concern to the malignancy of meningiomas.

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Citations

Jan 14, 2011·Clinical Neurology and Neurosurgery·George A AlexiouAthanasios P Kyritsis
Sep 8, 2005·Neurosurgery·Ashok Modha, Philip H Gutin
Jan 23, 2014·Journal of Neuro-oncology·Jeffrey J RaizerMarc Chamberlain

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