PMID: 11336983May 5, 2001Paper

Involvement of eddy currents in the mutagenicity of ELF magnetic fields

Mutation Research
Takao KoanaJunji Miyakoshi

Abstract

Possible carcinogenic and/or mutagenic activity of extremely low frequency magnetic fields was examined using somatic mutation and recombination test system of Drosophila melanogaster. An X-linked semi-dominant DNA repair defective mutation mei-41(D5) was introduced into the conventional mwh/flr test system to enhance mutant spot frequency. Virgin females of w mei-41(D5)/FM6; flr/TM6 were crossed with w mei-41(D5)/Y; mwh jv; spa(pol) males. The F(1) third instar larvae were exposed to a 50Hz, 20mT sinusoidal AC magnetic field for 24h. After moulting from pupal cases, their wings were examined under a bright field microscope to detect hair spots with mwh or flr mutant morphology. The exposure caused a statistically significant enhancement in somatic recombination spot frequency. Mutant spots arising due to chromosomal non-disjunction or terminal deletion also increased but the frequency of spots resulting from point mutation was not altered. The enhancement in the recombination spot frequency was suppressed to the control level when a culture medium without electrolytes was used during exposure. When larvae were exposed to a magnetic field in an annular dish, flies from the outer ring showed more mutant spots compared to those f...Continue Reading

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Citations

Mar 26, 2013·Cell Biochemistry and Biophysics·Dimitris J PanagopoulosConstantinos Lioliousis
Dec 8, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R Charlet de SauvageB Veyret
Oct 16, 2015·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Michael Bevington
Jan 31, 2014·International Journal of Radiation Biology·Danica DimitrijevićBranka Janać
Dec 9, 2020·Journal of Radiation Research·Yoshiharu Tanaka, Masakazu Furuta

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