PMID: 9660097Jul 11, 1998Paper

Involvement of endogenous nitric oxide signalling system in brain muscarinic acetylcholine receptor activation

Journal of Neural Transmission
T BordaG Cremaschi

Abstract

Biochemical signalling events coupled to muscarinic cholinergic receptors (mAChR), specifically those related to nitric oxide (NO) production, were studied on rat cerebral frontal cortex. The mAChR agonist carbachol was found to exert a specific biphasic action on NO synthase (NOS) activity: low doses ranging between 10(-9) M to 10(-7) M lead to NOS activation while higher doses (>10(-6) M) inhibited enzymatic activity. Carbachol stimulatory action was blunted by agents that interfere with calcium-calmodulin while a protein kinase (PKC) inhibitor, staurosporine was able to abrogate the inhibitory effect. Moreover, PKC activity showed maximum translocation to cerebral frontal cortex membranes with carbachol concentrations that inhibited NO production. Products from phosphoinosite (PI) hydrolysis are involved in these actions as carbachol was found to increase PI turnover in a dose dependent manner. These results would serve as an example of cross-talk between both enzymatic pathways.

Citations

Oct 9, 1999·Progress in Neurobiology·C Gottesmann
Aug 5, 2005·Visual Neuroscience·Alejandro BerraLeonor Sterin-Borda
Apr 12, 2014·PloS One·Chris LawArtur Kania
Apr 20, 2012·Cellular Immunology·Silvia ReinaEnri Borda
Sep 23, 2008·Journal of Chemical Neuroanatomy·Rosa M Giraldez-PerezRosario Pasaro
Aug 24, 2007·Biochemical Pharmacology·Leonor Sterin-BordaEnri Borda
Aug 2, 2006·Autonomic & Autacoid Pharmacology·M CasanovaE S Borda
Nov 21, 2009·Journal of Cellular Physiology·Silvia ReinaEnri Borda
Feb 22, 2005·Experimental Eye Research·Enri BordaLeonor Sterin-Borda
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Silvia ReinaEnri Borda
Jan 15, 2015·Stress : the International Journal on the Biology of Stress·Hana TomankovaJaromir Myslivecek
Oct 20, 2009·The International Journal of Neuropsychopharmacology·Sabrina GanzinelliLeonor Sterin-Borda
Apr 30, 2019·Frontiers in Neural Circuits·Cristina ColangeloSrikanth Ramaswamy
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania BordaLeonor Sterin-Borda
Jan 17, 2019·Cell and Tissue Research·Samia R L JocaGregers Wegener

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