Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors

Brain Research
Hee-Jae KimEun Joo Baik

Abstract

COX-2 and prostaglandins (PGs) might play important roles in epilepsy. In kainic acid-induced seizures, the brain largely increases PGD(2), first from COX-1 and later COX-2-induced PGF(2alpha). Pre-treatment with COX-2 inhibitors such as indomethacin, nimesulide, and celecoxib is known to aggravate kainic acid (KA)-induced seizure activity. However it is not known whether the proconvulsant effect of those non-steroidal anti-inflammatory drugs (NSAIDs) is due to changes in endogenous prostaglandins (PGs), or what types of PGs are involved. The purpose of this study was to determine the effect of intracisternally administered PGs on KA-induced seizures aggravated by pre- or post-treatment with COX-2 inhibitors. Systemic KA injection (10 mg/kg i.p.) in mice evoked mild seizure activity within 15 min. PGs were administrated intracisternally 20 min prior to KA administration. COX inhibitors (indomethacin, nimesulide, and ketoprofen, 10 mg/kg i.p.) were injected 1 h before or 15 min after KA. An additional COX-2 inhibitor, celecoxib, was administered orally. Intracisternally administered PGF(2alpha) (700 ng), but not PGD(2) (700 ng) or PGE(2) (700 ng) completely alleviated KA-induced seizures potentiated by COX-2 inhibitors, and also...Continue Reading

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Citations

Jun 19, 2013·CNS Drugs·Mercé FalipCarlos Cara
Nov 19, 2011·Epilepsia·Mirian Graciela Silva Stiebbe SalvadoriCarlos Fernando Mello
Nov 1, 2013·Journal of Neuroinflammation·Alexander V GlushakovSylvain Doré
May 28, 2014·Neurological Research·Oytun ErbaşDürdane Aksoy
Apr 24, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Suad A Al-AbriKent R Olson
Aug 16, 2016·Seizure : the Journal of the British Epilepsy Association·Lehong GaoYing Liu
Feb 19, 2017·Epilepsy Research·Beatrice Mihaela RaduGiuseppe Bertini
Apr 22, 2018·British Journal of Pharmacology·Najam A Sharif, Peter G Klimko
Nov 30, 2018·Expert Opinion on Therapeutic Targets·Asheebo RojasRaymond Dingledine
Jul 3, 2019·Nature Reviews. Neurology·Annamaria VezzaniTeresa Ravizza
Nov 2, 2019·Journal of Neuroinflammation·Chitra RawatRitushree Kukreti
Dec 7, 2017·Reviews in the Neurosciences·Sree LalithaBikash Medhi
Jul 29, 2020·Neurochemical Research·Ferit DurankuşOytun Erbaş
Nov 30, 2016·Frontiers in Neurology·Patrícia Gonçalves BarbalhoClaudia Vianna Maurer-Morelli
Nov 19, 2020·International Journal of Molecular Sciences·Cecilia Zavala-TecuapetlaHiram Luna-Munguia
Aug 20, 2019·Neuropharmacology·Gaetano TerroneAnnamaria Vezzani
Aug 28, 2019·Progress in Neurobiology·Ying YuJianxiong Jiang
Mar 8, 2011·Neurotoxicology·Dejan MilatovicMichael Aschner
Mar 3, 2011·Neuroscience Letters·Teresa RavizzaAnnamaria Vezzani

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