Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats

Brain Research
Juan DuShaoyang Chen

Abstract

Our previous study demonstrated that pretreatment with electroacupuncture (EA) elicited protective effects against transient cerebral ischemia through cannabinoid receptor type 1 receptor (CB1R). In the present study, we investigated whether or not the extracellular signal regulated-kinase 1/2 (ERK1/2) pathway was involved in the ischemic tolerance induced by EA pretreatment through CB1R. At 24h after the end of the last EA pretreatment, focal cerebral ischemia was induced by middle cerebral artery occlusion for 120min in rats. The neurological scores and infarct volumes were evaluated at 24h after reperfusion. The expression of p-ERK1/2 in the brains was also investigated in the presence or absence of CB1R antagonist AM251. EA pretreatment reduced infarct volumes and improved neurological outcome at 24h after reperfusion, and the beneficial effects were abolished by U0126. The blockade of CB1R by AM251 reversed the up-regulation of p-ERK1/2 expression induced by EA pretreatment. Our findings suggest that the ERK1/2 pathway might be involved in EA pretreatment-induced cerebral ischemic tolerance via cannabinoid CB1 receptor in rats.

References

Mar 28, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M GuzmánI Galve-Roperh
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·S NamuraA Alessandrini
Feb 1, 2005·European Journal of Pharmacology·David A KaranianBen A Bahr
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David PanikashviliEsther Shohami
Jul 30, 2005·Neuromolecular Medicine·Mario van der Stelt, Vincenzo Di Marzo
Oct 13, 2006·Neuroscience Letters·Jeong-Sun ChoiMun-Yong Lee
Feb 9, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tiziana RubinoDaniela Parolaro
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Gaëlle CorbilléJean-Antoine Girault
Sep 11, 2008·Current Pharmaceutical Design·Cecilia J Hillard
Jan 21, 2009·Molecular Neurobiology·Jean Lud Cadet, Irina N Krasnova

❮ Previous
Next ❯

Citations

May 12, 2012·Mediators of Inflammation·Luciano S A CapettiniFabrizio Montecucco
May 15, 2013·Journal of Neuroinflammation·Zhuqing JinPappachan E Kolattukudy
Jun 3, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Juan ZhangXiangrui Wang
Jan 15, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Huang NieQingrong Tan
May 23, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Xin LiLize Xiong
May 6, 2015·Expert Opinion on Therapeutic Targets·Demetrios MorisStamatios Theocharis
Aug 24, 2011·The International Journal of Neuropsychopharmacology·Paula FallopaJair Guilherme Santos
Aug 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Zhou-Quan WuZhi-Qing Zou
Nov 8, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Ling-Yong XiaoCun-Zhi Liu
Sep 25, 2012·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Yao-Bin Long, Xiao-Ping Wu
Jul 8, 2020·International Journal of Molecular Sciences·Tzu-Hsuan Wei, Ching-Liang Hsieh
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiang-Chun LaiChing-Liang Hsieh
Nov 25, 2020·Neural Regeneration Research·Bing-Qian CaoPeng-Hui Lai
Mar 6, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cen YangLize Xiong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.