Involvement of estrogens in the regulation of granulosa cell aromatase activity

Canadian Journal of Physiology and Pharmacology
S A Daniel, D T Armstrong

Abstract

Androgens have been shown to enhance follicle-stimulating hormones (FSH) induced aromatase activity in cultured granulosa cells obtained from the ovaries of immature rats, however, aromatizable androgens are more effective than nonaromatizable androgens. The present study was designed to investigate the possibility that aromatization of androgens to estrogens is responsible for the greater effectiveness of aromatizable androgens. Granulosa cells were cultured during a 36-h induction period in the presence of FSH, FSH + testosterone, or FSH + dihydrotestosterone with or without 4-acetoxy-4-androstene-3,17-dione (4-acetoxy-A), an inhibitor of aromatase activity. Treatment with androgens enhanced aromatase activity measured as accumulation of estradiol-17 beta during a 6-h test period with testosterone added as substrate. The effects of both androgens on FSH-induced aromatase activity were blocked by 4-acetoxy-A. Presence of a high concentration of diethylstilbestrol (DES), a synthetic estrogen, during the induction period had a significant positive effect on FSH-induced estradiol-17 beta accumulation during the test period. All lower doses were ineffective. Nafoxidine, an antiestrogen known to inhibit binding of estrogens to thei...Continue Reading

Citations

Jun 1, 1987·Cell and Tissue Research·R J HutzD J Dierschke
Jan 1, 1987·Journal of Steroid Biochemistry·S G Hillier
Aug 10, 2012·Molecular and Cellular Endocrinology·R Jeffrey Chang, Heidi Cook-Andersen
Feb 12, 2017·Reproductive Biology and Endocrinology : RB&E·Michael V HomerR Jeffrey Chang
Dec 21, 2018·Health Care for Women International·Ashish Kumar SinghGovind Sharan Dangayach
Jun 16, 2001·Endocrine Reviews·S F PalterE Y Adashi
May 8, 2018·Reproductive Biology and Endocrinology : RB&E·Xiaoyu TuZhaogui Sun

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