Involvement of extracellular matrix proteins in the course of experimental paracoccidioidomycosis

FEMS Immunology and Medical Microbiology
Angel GonzálezLuz E Cano

Abstract

We aimed at determining involvement of extracellular matrix proteins (ECMp) and an ECM-binding adhesin (32-kDa protein) from Paracoccidioides brasiliensis, in the course of experimental paracoccidioidomycosis. BALB/c mice were infected with P. brasiliensis conidia previously incubated with soluble laminin, fibronectin and fibrinogen or a mAb against the fungal adhesin. Inflammatory response, chitin levels and cytokine production at different postinfection periods were determined. Chitin was significantly decreased in lungs of mice infected with ECMp-treated conidia when compared with controls at week 8, especially with laminin and fibrinogen. Contrariwise, when animals were infected with mAb-treated conidia no differences in chitin content were found. The observed inflammatory reaction in lungs was equivalent in all cases. IFN-gamma increased significantly in lungs from mice infected with soluble ECMp - (at day 4 and week 12) or mAb-treated conidia (at week 12) when compared with animals infected with untreated conidia. Significant increased levels of tumour necrosis factor-alpha were observed at 8 weeks in animals infected with ECMp-treated conidia while no differences were observed during the remaining periods. These findings...Continue Reading

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Citations

Dec 21, 2010·Revista iberoamericana de micología·Gioconda San-Blas, Eva Burger
Dec 5, 2015·Frontiers in Microbiology·Haroldo C de OliveiraMaria J S Mendes-Giannini
Apr 19, 2015·BMC Microbiology·Edilânia Gomes Araújo ChavesCélia Maria de Almeida Soares
Apr 11, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pranita P SarangiYoshihiko Yamada
Dec 16, 2019·Inflammation·Papiya ChakrabortyPranita P Sarangi

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