Involvement of fibrocytes in asthma and clinical implications

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
S Mattoli

Abstract

Bloodborne fibrocytes are bone marrow-derived cells that participate in immune responses and exhibit pro-inflammatory and matrix remodelling properties. In patients with asthma receiving an adequate treatment, the blood fibrocyte count is very low and comparable to that obtained in healthy individuals. In these patients, a transient increase in fibrocyte numbers in the peripheral blood and in the airways occurs in concomitance with increased bronchial inflammation and reflects disease worsening and the need for more intensive treatment. Persistently elevated numbers of fibrocytes in the peripheral blood and in the bronchial mucosa are observed in chronically undertreated or corticosteroid-resistant asthma and are associated with persistent airway inflammation and ongoing remodelling of the bronchial wall. The asthmatic bronchial epithelium is the main source of fibrocyte chemoattractants in asthma and contributes with T helper type 2 lymphocytes and eosinophils to promote the proliferation and pro-remodelling function of recruited fibrocytes. The presence of elevated numbers of fibrocytes in the bronchial mucosa of allergic patients with undertreated or treatment-resistant asthma may also increase the risk of acute exacerbation...Continue Reading

References

Nov 1, 1990·American Journal of Respiratory Cell and Molecular Biology·C E BrewsterW R Roche
Jan 1, 1990·International Archives of Allergy and Applied Immunology·G Zwadlo-KlarwasserW Schmutzler
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·G A TennentM B Pepys
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·A Schmitt-GräffG Gabbiani
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ChesneyR Bucala
Aug 26, 1998·BioTechniques·A K Robbins, R A Horlick
Mar 10, 1999·Journal of Clinical Pathology·J OertelD Huhn
Feb 3, 2000·Mechanisms of Ageing and Development·H ShiraiT Kodama
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A DzionekJ Schmitz
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R AbeC N Metz
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I HartlappC N Metz
Nov 6, 2002·The Journal of Allergy and Clinical Immunology·Gaëtan DesléeJoël Pestel
Apr 2, 2003·The Journal of Cell Biology·Lars H EngelholmThomas H Bugge
May 27, 2003·The European Respiratory Journal·M HoshinoT Nakagawa
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias SchmidtSabrina Mattoli
Aug 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Claus-Werner FranzkeLeena Bruckner-Tuderman
Dec 31, 2003·Trends in Genetics : TIG·Johanna Myllyharju, Kari I Kivirikko
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·Sandra C DormanRoma Sehmi
Jan 18, 2006·American Journal of Respiratory and Critical Care Medicine·Antje PrasseGernot Zissel
Mar 31, 2006·Respiratory Research·Kristian NihlbergGunilla Westergren-Thorsson
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raquel Muñoz-FernándezEnrique G Olivares
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamal I SaadaDon W Powell
Nov 9, 2006·The Journal of Biological Chemistry·Masanobu TakejiTakeshi Miwa
May 1, 2007·Arthritis and Rheumatism·Antje PrasseJoachim Müller-Quernheim
Jun 30, 2007·American Journal of Respiratory Cell and Molecular Biology·Tiegang LiuUsamah S Kayyali
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alberto Bellini, Sabrina Mattoli
Sep 20, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jean-Luc FaucherJean Feuillard
Feb 5, 2008·American Journal of Respiratory and Critical Care Medicine·Gail M GauvreauPaul M O'Byrne
Jun 28, 2008·American Journal of Respiratory and Critical Care Medicine·Chun-Hua WangHan-Pin Kuo
Jul 1, 2008·Applied and Environmental Microbiology·William C SchumacherAndrew J Phipps
Sep 13, 2008·Cell Stem Cell·Mihaela CrisanBruno Péault

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Citations

Jan 18, 2016·Allergologia et immunopathologia·H KobayashiY Takei
Aug 5, 2015·Journal of Zhejiang University. Science. B·Sabrina Mattoli
Jun 25, 2019·Arthritis & Rheumatology·Maria NicastroAugusto Vaglio
Aug 11, 2019·International Journal of Molecular Sciences·Luís Fonseca BritoFelix R Stahl
Oct 6, 2020·Frontiers in Pharmacology·Xueyi ZhuJingcheng Dong
Nov 22, 2018·Frontiers in Immunology·Darrell Pilling, Richard H Gomer
Jul 31, 2021·The Clinical Respiratory Journal·Xiujuan YaoLuo Zhang

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