Involvement of fractalkine and macrophage inflammatory protein-1 alpha in moderate-severe depression

Mediators of Inflammation
Rosaria Alba MerendinoSebastiano Gangemi

Abstract

Moderate-severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein-1 alpha (MIP-1alpha) are, respectively, members of CX3C and C-C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP-1alpha in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP-1alpha was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.

References

May 9, 2001·The Journal of Clinical Investigation·P FraticelliA Mantovani
May 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S O V NunesM S Kaminami
Oct 25, 2002·Mediators of Inflammation·Rosaria Alba MerendinoSebastiano Gangemi

❮ Previous
Next ❯

Citations

Feb 24, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Harris A EyreBernhard T Baune
May 2, 2009·Brain, Behavior, and Immunity·Elisa BrietzkeFlávio Kapczinski
Aug 25, 2015·Brain, Behavior, and Immunity·Sioui Maldonado-BouchardMichelle A Hook
May 9, 2018·Menopause : the Journal of the North American Menopause Society·Antonino CatalanoNunziata Morabito
Oct 31, 2019·Stress : the International Journal on the Biology of Stress·Whitney CowellRosalind J Wright
Nov 16, 2019·Current Neuropharmacology·Katarzyna ChameraAgnieszka Basta-Kaim
Sep 3, 2020·World Journal of Psychiatry·Francisco Rafael de la PeñaLenin Pavón
Oct 18, 2020·International Journal of Molecular Sciences·Patrizia AmadioSilvia Stella Barbieri
Aug 6, 2021·Neuropsychiatric Disease and Treatment·Xiuli WangFuping Shi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
N M SimonK K Wong
Progress in Neuro-psychopharmacology & Biological Psychiatry
A L TeixeiraMarco Aurelio Romano-Silva
© 2022 Meta ULC. All rights reserved