PMID: 9378250Sep 1, 1997Paper

Involvement of functional antagonism in the effects of adenosine antagonists and L-NAME in the rat isolated heart

General Pharmacology
C D Lewis, S M Hourani

Abstract

1. Adenosine and its analogues induced an increase in flow rate when infused into the rat isolated perfused heart. The agonist potency order obtained was 2-(rho-(2-carboxyethyl)phenethyl-amino)-5'-N-ethylcarboxamidoadenosine (CGS 21680) > or = 5'-N-ethylcarboxamidoadenosine (NECA) > N6-cyclopentyladenosine = adenosine, although the maximal response obtained for CGS 21680 was only 70% of that achieved by NECA. NG-Nitro-L-arginine methyl ester (L-NAME), the nonselective adenosine antagonist 8-rho-(sulfophenyl)theophylline (8-SPT) and the A2a selective antagonist N-[2-(dimethylamino)ethyl]-N-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3- diprophyl-1H-purin-8-yl)benzene sulfonamide (PD 115, 119) reduced responses to the adenosine agonists, but some of this reduction was shown to be due to a nonspecific decrease in flow rate as well as a specific inhibitory action. 2. When this functional antagonism is taken into account, the results suggest that the increase in flow rate induced by the adenosine agonists was mediated by A2 receptors, with the increase in flow rate induced by CGS 21680 mediated by A2a receptors, whereas that induced by NECA was mediated by A2b receptors. 3. L-NAME did not appear to have any effect on the increase in fl...Continue Reading

References

Oct 20, 1992·European Journal of Pharmacology·S R MakujinaS J Mustafa
Jan 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·R F BrunsS J Hays
Nov 16, 1987·Life Sciences·H W HamiltonR F Bruns
Sep 15, 1994·European Journal of Pharmacology·J O Schiele, U Schwabe
Nov 1, 1994·General Pharmacology·C D LewisM G Collis
Jul 1, 1994·Trends in Pharmacological Sciences·R Schulz, C R Triggle
Jun 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·G CristalliR A Olsson
Oct 1, 1993·Trends in Pharmacological Sciences·M G Collis, S M Hourani
Jul 1, 1993·British Journal of Pharmacology·M F GurdenC J Vardey
May 1, 1993·Trends in Cardiovascular Medicine·A M Shah, M J Lewis

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Citations

Oct 31, 2006·Pflügers Archiv : European journal of physiology·Laura Willems, John P Headrick
Aug 7, 2001·British Journal of Pharmacology·A Flood, J P Headrick
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Roselyn B Rose'Meyer
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Dec 25, 2002·Journal of Cardiovascular Pharmacology·Andrea K HinschenJohn P Headrick
Mar 27, 2003·Journal of Cardiovascular Pharmacology·M A Hassan TalukderS Jamal Mustafa
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A K HinschenJ P Headrick
Aug 22, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Habib R AnsariS Jamal Mustafa
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderS Jamal Mustafa
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderS Jamal Mustafa
Mar 24, 2021·Basic Research in Cardiology·Ying ZhangZhichao Zhou

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