Involvement of GABAB receptor systems in experimental depression: baclofen but not bicuculline exacerbates helplessness in rats

Brain Research
Y NakagawaT Takashima

Abstract

There are two gamma-aminobutyric acid (GABA) hypotheses of the antidepressants action: an increase in GABAA neurotransmission or a decrease in GABAB neurotransmission may contribute to action of antidepressants. In this study, involvement of GABAA and GABAB receptor systems was examined in the learned helplessness paradigm in rats. Rats were injected with bicuculline or baclofen for 14 days. On day 14, the rats were subjected to 15 inescapable shocks. On day 15, they underwent the 40-trial escape test. Baclofen exacerbated the escape failures in the rats subjected to the inescapable shocks, although baclofen had no effects in the animals without shock pre-treatment. Bicuculline failed to influence the escape failures in the rats with the 15-shock pre-treatment. These results suggest that the long-term increase in GABAB neurotransmission but not the long-term attenuation of GABAA neurotransmission may be related to helplessness in rats.

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Citations

Oct 21, 1999·European Journal of Pharmacology·Y NakagawaT Takashima
Oct 13, 1998·Life Sciences·I S Shiah, L N Yatham
May 5, 2001·Psychoneuroendocrinology·M Molina-Hernández, N P Téllez-Alcántara
Jan 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas I F H CremersBen H C Westerink
Mar 1, 2012·Journal of Pharmacology & Pharmacotherapeutics·Dinesh Dhingra, Parul Joshi
Jan 26, 2011·European Journal of Pharmacology·Styliani VlachouAthina Markou
Aug 26, 2010·British Journal of Pharmacology·Subroto GhoseSalvatore J Enna
Jan 5, 2005·Trends in Pharmacological Sciences·John F Cryan, Klemens Kaupmann
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cedric MombereauJohn F Cryan
Dec 14, 2018·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Miho Terunuma
Nov 23, 2006·Depression and Anxiety·Allan V Kalueff, David J Nutt
Jul 31, 2003·Molecular Psychiatry·P BrambillaJ C Soares

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