Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.

Molecular and Cellular Biochemistry
Ethel Antunes WilhelmCristina Wayne Nogueira

Abstract

In this study, we investigated the role of GABAergic and glutamatergic systems in the anticonvulsant action of 3-alkynyl selenophene (3-ASP) in a pilocarpine (PC) model of seizures. To this purpose, 21 day-old rats were administered with an anticonvulsant dose of 3-ASP (50 mg/kg, per oral, p.o.), and [(3)H]γ-aminobutyric acid (GABA) and [(3)H]glutamate uptakes were carried out in slices of cerebral cortex and hippocampus. [(3)H]GABA uptake was decreased in cerebral cortex (64%) and hippocampus (58%) slices of 21 day-old rats treated with 3-ASP. In contrast, no alteration was observed in [(3)H]glutamate uptake in cerebral cortex and hippocampus slices of 21 day-old rats that received 3-ASP. Considering the drugs that increase synaptic GABA levels, by inhibiting its uptake or catabolism, are effective anticonvulsants, we further investigated the possible interaction between sub-effective doses of 3-ASP and GABA uptake or GABA transaminase (GABA-T) inhibitors in PC-induced seizures in 21 day-old rats. For this end, sub-effective doses of 3-ASP (10 mg/kg, p.o.) and DL-2,4-diamino-n-butyric acid hydrochloride (DABA, an inhibitor of GABA uptake--2 mg/kg, intraperitoneally; i.p.) or aminooxyacetic acid hemihydrochloride (AOAA; a GABA-...Continue Reading

References

Apr 1, 1995·Clinical Biochemistry·F M Sherif, S S Ahmed
Nov 1, 1994·Progress in Neurobiology·N C Danbolt
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Jul 21, 2000·Current Pharmaceutical Design·P Krogsgaard-LarsenK Frydenvang
Jul 31, 2001·CNS Drugs·S J Czuczwar, P N Patsalos
Aug 25, 2001·Epilepsia·D M Treiman
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Y H RaolA R Brooks-Kayal
Jan 29, 2003·Current Opinion in Pharmacology·Dorothy M Jones-Davis, Robert L Macdonald
Feb 20, 2003·Bulletin of Environmental Contamination and Toxicology·E N MacielV Folmer
Apr 2, 2004·Neurobiology of Disease·Nicholas J Maragakis, Jeffrey D Rothstein
Jan 11, 2005·Current Topics in Medicinal Chemistry·Piotr CzapińskiStanislaw J Czuczwar
Nov 8, 2006·British Journal of Pharmacology·P M Beart, R D O'Shea
Jun 23, 2009·Pharmacology, Biochemistry, and Behavior·Ethel A WilhelmLucielli Savegnago
Apr 17, 2010·Cell Biology and Toxicology·Ethel Antunes WilhelmCristina Wayne Nogueira
Mar 8, 2011·Current Opinion in Neurology·Simon Shorvon

❮ Previous
Next ❯

Citations

Dec 7, 2013·Psychopharmacology·Bibiana Mozzaquatro GaiCristina Wayne Nogueira
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola S HellwigEder J Lenardão
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola S HellwigEder J Lenardão

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.