Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage

PloS One
Sunao ShimadaYasuhiro Fujiwara

Abstract

Gliadin, a component of wheat gluten known to be an important factor in the etiology of celiac disease, is related to several other diseases through its enhancing effect on intestinal paracellular permeability. We investigated the significance of gliadin in non-steroidal anti-inflammatory drug (NSAID)-induced small-intestinal damage in mice. 7-week-old C57BL/6 male mice were divided into the following groups: standard diet group, in which mice were fed with wheat-containing standard rodent diet (CE-2); gluten-free diet group, in which mice were fed with gluten-free diet (AIN-76A); and gliadin-administered group, in which mice fed with gluten-free diet were administered with gliadin (~250 mg/kg BW). Each group was subdivided into negative, healthy control group and NSAID-treated group. To some mice fed with gluten-free diet and administered with gliadin, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor was administered for clarification of the significance of EGFR in NSAID-induced small intestinal damage and intestinal permeability. In mice fed with a gluten-free diet, indomethacin or diclofenac induced very mild mucosal damage in the small intestine compared with that in mice fed with a wheat-containing standar...Continue Reading

References

Nov 21, 1998·Gut·G SigthorssonI Bjarnason
Jan 13, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David Y GrahamWaqar A Qureshi
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jay L GoldsteinUNKNOWN Investigators
May 12, 2005·Gastroenterology·Laurence MaidenIngvar Bjarnason
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen E ThomasStefanie N Vogel
Apr 26, 2006·Scandinavian Journal of Gastroenterology·Sandro DragoAlessio Fasano
Sep 30, 2006·Food Microbiology·Herbert Wieser
Dec 8, 2006·Archives of Toxicology·Molly JacobIngvar Bjarnason
Jan 16, 2007·The Journal of Pharmacology and Experimental Therapeutics·C B ForsythA Keshavarzian
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Francesco RaimondiRoberto Paludetto
May 17, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L Bueno, J Fioramonti
Nov 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Toshio WatanabeTetsuo Arakawa
Jul 2, 2009·Journal of Gastroenterology·Kazuhide HiguchiTetsuo Arakawa
Sep 15, 2009·Schizophrenia Research·Diana SamarooArmin Alaedini
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Amit TripathiAlessio Fasano
Mar 6, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yong ZhouLenard M Lichtenberger
Aug 21, 2010·Inflammatory Bowel Diseases·Sa'ad Y Salim, Johan D Söderholm
May 16, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CamilleriG N Verne
Jan 22, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Toshio WatanabeTetsuo Arakawa
Mar 14, 2013·Nutrients·Karin de Punder, Leo Pruimboom
May 30, 2014·Diabetologia·Julie C AntvorskovKarsten Buschard
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Sheweta BarakB S Khatkar
Dec 3, 2014·Clinical and Experimental Medicine·Olimpia VincentiniMarco Silano
Oct 7, 2015·BMJ : British Medical Journal·Benjamin LebwohlPeter H R Green
Oct 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuhong GuoThomas Y Ma
Apr 29, 2018·Molecular Nutrition & Food Research·Charlene B Van BuitenRyan J Elias
Jun 14, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shoko EdogawaMadhusudan Grover
Nov 2, 2018·Multiple Sclerosis and Related Disorders·Henriette Lynge ThomsenJette Lautrup Frederiksen

❮ Previous
Next ❯

Citations

Feb 8, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Hiroshi YamawakiKatsuhiko Iwakiri
Dec 23, 2019·Journal of Gastroenterology·Toshio WatanabeFrancis K L Chan
Jan 6, 2021·Nutrients·Deshiré Alpízar-RodríguezBenoît Gilbert
Mar 7, 2021·Nature Reviews. Rheumatology·Mario M ZaissFrancesco Ciccia
Jul 1, 2020·Terapevticheskiĭ arkhiv·E N Kareva

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
ELISA
PCR
Protein Assay

Software Mentioned

ImageJ
ImageQuant TL Analysis Toolbox

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.