PMID: 698217Sep 11, 1978Paper

Involvement of glycoconjugates in insulin-receptor interactions. Studies in liver plasma membranes of control and diabetic mice

Biochimica Et Biophysica Acta
M CaronP Kern

Abstract

The involvement of glycoconjugates in the insulin-receptor interactions in mouse liver is tested by digestions of membranes with various enzymes. Trypsin decreased the binding of [125I]insulin to liver membranes. After digestion with beta-galactosidase no "high affinity'' receptor sites could be detected. The effects observed with plant lectins confirm the involvement of galactoconjugates in the insulin binding process. Sophora japonica and Ricinus communis lectins (with galactose specificity) and concanavalin A largely inhibit the binding process of insulin and those effects concern the "high affinity'' receptor sites. Other lectins (wheat germ agglutinin, Dolichos) and enzymes (alpha-L-fucosidase, beta-N-acetyl-hexosaminidase and neuraminidase) are without effect on insulin binding. Comparative studies performed on diabetic mouse liver membrane (KK mice), previously characterized by decreased number of insulin receptors, are in good agreement with qualitatively similar receptor sites in both non-diabetic (control) and diabetic mice. Effects of enzymes and lectins yielded same results as compared to control membranes. Plasma membrane proteins and glycoproteins in both types of mouse are indistinguishable with respect to enzymi...Continue Reading

References

Feb 14, 1977·Biochimica Et Biophysica Acta·V ChandramouliJ R Carter
May 6, 1975·Biochimica Et Biophysica Acta·P KernD Veissière
Jan 6, 1970·Biochimica Et Biophysica Acta·T K Ray
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R GavinD N Buell
Jan 1, 1973·Annual Review of Biochemistry·H Lis, N Sharon
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Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON

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Citations

May 1, 1982·Basic Research in Cardiology·J EckelH Reinauer
May 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H O JaureguiS Naik
Jun 28, 1985·Biochemical and Biophysical Research Communications·Y Fujita-YamaguchiS Kathuria
Mar 30, 1979·Biochemical and Biophysical Research Communications·T Momoi
Nov 1, 1982·Molecular and Cellular Endocrinology·G CherquiJ Picard
Sep 1, 1981·Molecular and Cellular Endocrinology·G CherquiJ Picard
Nov 30, 1984·Biochemical and Biophysical Research Communications·J PodskalnyP Gorden
May 1, 1979·Human Pathology·L Jarett

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