Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort

Brain and Behavior
Joanne RyanMarie-Laure Ancelin

Abstract

Despite the explosion in genetic association studies over the last decade, clearly identified genetic risk factors for depression remain scarce and replication studies are becoming increasingly important. G-protein-coupled receptor 50 (GPR50) has been implicated in psychiatric disorders in a small number of studies, although not consistently. Data were obtained from 1010 elderly men and women from the prospective population-based ESPRIT study. Logistic regression and survival models were used to determine whether three common GPR50 polymorphisms were associated with depression prevalence or the incidence of depression over 12-years. The analyses were adjusted for a range of covariates such as comorbidity and cholesterol levels, to determine independent associations. All three variants showed some evidence of an association with late-life depression in women, although these were not consistent across outcomes, the overall effect sizes were relatively small, and most would not remain significant after correction for multiple testing. Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor ...Continue Reading

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Citations

Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Zahid KhanXuxu Zhuang
Dec 20, 2016·Oncotarget·Xinzhu ZhangRena Li
Aug 15, 2018·Brain Sciences·Paulo Pinares-GarciaJoohyung Lee
Jul 1, 2020·Genes·Lyndsay R Watkins, Cesare Orlandi
Jul 23, 2020·Neurochemical Research·Qifa LiShao Li

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Methods Mentioned

BETA
genotyping
PCR
FRET

Software Mentioned

Haploview
KlusterCaller
SAS

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