Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

Gut Microbes
P D CaniAmandine Everard

Abstract

Obesity is associated with metabolic alterations related to glucose homeostasis and cardiovascular risk factors. These metabolic alterations are associated with low-grade inflammation that contributes to the onset of these diseases. We and others have provided evidence that gut microbiota participates in whole-body metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders. Recently, we defined gut microbiota-derived lipopolysaccharide (LPS) (and metabolic endotoxemia) as a factor involved in the onset and progression of inflammation and metabolic diseases. In this review, we discuss mechanisms involved in the development of metabolic endotoxemia such as the gut permeability. We also discuss our latest discoveries demonstrating a link between the gut microbiota, endocannabinoid system tone, leptin resistance, gut peptides (glucagon-like peptide-1 and -2), and metabolic features. Finally, we will introduce the role of the gut microbiota in specific dietary treatments (prebiotics and probiotics) and surgical interventions (gastric bypass).

References

Jan 1, 1977·Annual Review of Microbiology·D C Savage
Jun 1, 1995·The Journal of Nutrition·G R Gibson, M B Roberfroid
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Mar 10, 2001·Cell·B M Spiegelman, J S Flier
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita C E VreugdenhilWim A Buurman
Jan 24, 2003·Diabetes·Younes Anini, Patricia L Brubaker
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhiping LiAnna Mae Diehl
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·C D Sjöström
Oct 14, 2003·Microbes and Infection·Fredrik BäckhedAgneta Richter-Dahlfors
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Dec 24, 2004·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study Scientific Group
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Jun 9, 2005·Journal of Clinical Gastroenterology·Carmela LoguercioCamillo Del Vecchio Blanco
Dec 13, 2005·European Journal of Clinical Nutrition·P D CaniN M Delzenne
Mar 24, 2006·Molecular Microbiology·Erwin G ZoetendalWillem M de Vos
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Isabel MatiasVincenzo Di Marzo
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paola BrunDiego Martines
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 26, 2006·Cellular and Molecular Life Sciences : CMLS·V GasperiM Maccarrone
Jan 11, 2007·Biochemical and Biophysical Research Communications·Takayoshi SuganamiYoshihiro Ogawa
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Mar 21, 2007·The British Journal of Nutrition·Patrice D CaniNathalie M Delzenne
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
Oct 24, 2007·The Journal of Nutrition·Nathalie M DelzenneAudrey M Neyrinck
Oct 24, 2007·Nature Medicine·Ekihiro SekiRobert F Schwabe
Nov 10, 2007·The American Journal of Clinical Nutrition·Clett ErridgeDavid J Webb
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Patrice D Cani, Nathalie M Delzenne
Dec 20, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Didier M Lambert, Giulio G Muccioli
Feb 2, 2008·Nature Reviews. Drug Discovery·Wei JiaJeremy K Nicholson
Mar 11, 2008·The American Journal of Clinical Nutrition·Marko KalliomäkiErika Isolauri

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Citations

May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Amandine EverardPatrice D Cani
Apr 26, 2013·Briefings in Functional Genomics·Patrice D Cani
Jan 10, 2013·Current Opinion in Lipidology·Milan K PiyaPhilip G McTernan
Mar 29, 2013·Science Translational Medicine·Alice P LiouLee M Kaplan
Aug 21, 2013·Postgraduate Medical Journal·Marc BardouMyriam Martel
Jul 6, 2014·PloS One·Antonella NapolitanoDerek J Nunez
Jan 16, 2014·Journal of Physiological Anthropology·Eva M SelhubAlison C Bested
Aug 14, 2013·European Journal of Endocrinology·Leontine E H BakkerIngrid M Jazet
Nov 16, 2013·The British Journal of Nutrition·Nicole J KellowChristopher M Reid
Jan 7, 2014·The Journal of Endocrinology·Raylene A ReimerSimon Wood
Jun 28, 2014·BioMed Research International·Nuria SalazarPatricia Ruas-Madiedo
Oct 1, 2014·The British Journal of Nutrition·Roger Clemens, B Jan-Willem van Klinken
Oct 20, 2014·Reviews in Endocrine & Metabolic Disorders·Patrick MathieuJean-Pierre Després
Jul 16, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Eibhlís M O'Connor
Feb 18, 2016·Nutrition Reviews·Marie-Edith Arnal, Jean-Paul Lallès
Sep 21, 2013·Scandinavian Journal of Gastroenterology·Malin WerlingCarel W Le Roux
Sep 18, 2015·International Journal of Environmental Research and Public Health·Seung Jin HanDae Jung Kim
Oct 22, 2013·Expert Review of Clinical Immunology·Pjotr BekkeringGer T Rijkers
Dec 30, 2014·Nutrients·Michael A Conlon, Anthony R Bird
Nov 3, 2015·Scandinavian Journal of Immunology·Noriko MatsushitaJunji Yagi
Mar 3, 2015·Pediatric Obesity·S J MillerJ N Davis
Aug 11, 2015·Molecular Nutrition & Food Research·Manuel Gómez-GuzmánJuan Duarte
Dec 30, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L-G HersougS Loft
Oct 29, 2015·Environmental Toxicology and Pharmacology·Sun-Young AhnJae-Hwan Nam
Dec 10, 2015·European Journal of Endocrinology·Andressa CoopeLicio A Velloso
Mar 31, 2015·European Journal of Pharmacology·Melania Osto, Thomas A Lutz
Apr 23, 2013·Clinical and Experimental Immunology·M C SimonN C Schloot
May 15, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N V DhurandharP D Cani
May 29, 2014·Molecular Nutrition & Food Research·Isabel SeiquerMaría Pilar Navarro
Nov 19, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·F HortonM D Robertson
Mar 24, 2016·Current Diabetes Reports·Jennifer E Below, Esteban J Parra

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