Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Marjorie BarrierArnaud Courtois

Abstract

Particulate air pollution exerts deleterious effects on cardiovascular system. We previously described that exposure to urban particulate matter (SRM1648) impairs nitric oxide (NO, a major vasculoprotective factor) responsiveness in intrapulmonary arteries. As Heme Oxygenase-1 (HO-1) is induced by urban particles in some cell types and is known to alter NO-dependent signaling pathway, the objective was to characterize HO-1 involvement in SRM1648-induced impairment of NO-dependent relaxation in intrapulmonary arteries. Rat intrapulmonary artery rings were exposed or not to Co (III) Protoporphyrin IX Chloride (HO-1 inducer) or SRM1648 in the absence or presence of Cr (III) Mesoporphyrin IX Chloride (HO-1 activity inhibitor). NO-dependent relaxation was assessed with DEA-NOnoate (DEA-NO) on pre-contracted arteries. HO-1 and soluble guanylyl-cyclase (sGC) mRNA and protein expressions were assessed by qRT-PCR and Western blotting, respectively. SRM1648 or Co (III) Protoporphyrin IX Chloride exposure (24) impaired DEA-NO-dependent relaxation. The SRM-induced alteration of DEA-NO responsiveness was partially prevented by Cr (III) Mesoporphyrin IX Chloride. Co (III) Protoporphyrin IX Chloride induced HO-1 mRNA and protein expressions, ...Continue Reading

References

Mar 22, 2000·Circulation·D R GoldR Verrier
May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L Calderón-GarcidueñasR B Devlin
Jul 11, 2002·Biochemical Pharmacology·Markus Koglin, Sönke Behrends
Jul 19, 2002·Cardiovascular Research·Michael T Gewaltig, Georg Kojda
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Nov 29, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Beek Yoke ChinTerence H Risby
Dec 4, 2002·Environmental Health Perspectives·Joao R F BatalhaJohn J Godleski
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mayumi KajimuraMakoto Suematsu
May 26, 2004·Biochimica Et Biophysica Acta·Errol ThomsonRenaud Vincent
Aug 5, 2005·Environmental Health Perspectives·Bruce UrchRobert D Brook
Oct 1, 2005·Inhalation Toxicology·Andrew J Ghio, Mitchell D Cohen
Jun 16, 2006·Inhalation Toxicology·Pernilla WiebertMagnus Svartengren
Aug 10, 2007·Environmental Health Perspectives·Lilian Calderón-GarcidueñasWilliam Reed
Sep 22, 2007·Chemical Research in Toxicology·Rafik BachoualSophie Lanone
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Andrew J GhioKent E Pinkerton
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Nicholas L MillsDavid E Newby
Apr 2, 2009·Environmental Health Perspectives·Carlo R BartoliJohn J Godleski
Mar 21, 2012·Hypertension·Kristen E CosselmanJoel D Kaufman
Jun 5, 2012·Circulation. Heart Failure·Loren E WoldSanjay Rajagopalan
Jul 24, 2012·Pflügers Archiv : European journal of physiology·Elodie MartinThomas Ducret
Sep 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Sarah MahneKurt J Varner
Sep 11, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sabine H van RijtSilke Meiners
Jul 31, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Subramanian KarthikeyanRenaud Vincent
Dec 11, 2014·European Heart Journal·David E NewbyUNKNOWN ESC Heart Failure Association

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Citations

Dec 5, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jean SelimJean-Marc Baste
Mar 20, 2018·Current Opinion in Physiology·Vineeta TanwarLoren E Wold
Jul 10, 2017·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J DeweirdtI Baudrimont

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