PMID: 9192688Jun 24, 1997Paper

Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats

Proceedings of the National Academy of Sciences of the United States of America
R BernabeuJ H Medina

Abstract

cAMP/cAMP-dependent protein kinase (PKA) signaling pathway has been recently proposed to participate in both the late phase of long term potentiation in the hippocampus and in the late, protein synthesis-dependent phase of memory formation. Here we report that a late memory consolidation phase of an inhibitory avoidance learning is regulated by an hippocampal cAMP signaling pathway that is activated, at least in part, by D1/D5 receptors. Bilateral infusion of SKF 38393 (7.5 microg/side), a D1/D5 receptor agonist, into the CA1 region of the dorsal hippocampus, enhanced retention of a step-down inhibitory avoidance when given 3 or 6 h, but not immediately (0 h) or 9 h, after training. In contrast, full retrograde amnesia was obtained when SCH 23390 (0.5 microg/side), a D1/D5 receptor antagonist, was infused into the hippocampus 3 or 6 h after training. Intrahippocampal infusion of 8Br-cAMP (1.25 microg/side), or forskolin (0.5 microg/side), an activator of adenylyl cyclase, enhanced memory when given 3 or 6 h after training. KT5720 (0.5 microg/side), a specific inhibitor of PKA, hindered memory consolidation when given immediately or 3 or 6 h posttraining. Rats submitted to the avoidance task showed learning-specific increases in...Continue Reading

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Citations

Sep 24, 1999·Journal of Neuroscience Research·M WaltonM Dragunow
Jan 21, 2000·Hippocampus·V Ramírez-AmayaF Bermúdez-Rattoni
Jul 12, 2002·Journal of Neuroscience Research·Akira NagakuraSatoshi Takeo
Aug 25, 2004·Neurotoxicity Research·Lionel Muller IgazJorge H Medina
Nov 20, 2004·Psychopharmacology·Daniel S KerrMartín Cammarota
May 10, 2006·European Archives of Psychiatry and Clinical Neuroscience·André F CarvalhoMárcia L F Chaves
Jun 7, 2012·Amino Acids·Mauren Assis SouzaLuiz Fernando Freire Royes
Aug 3, 2005·Cellular and Molecular Neurobiology·Martín CammarotaIván Izquierdo
Apr 25, 2006·Cellular and Molecular Neurobiology·Francine TramontinaCarlos-Alberto Gonçalves
May 3, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jesper EkelundMarc Laruelle
Jul 9, 2013·Neurobiology of Learning and Memory·Cynthia KatcheJorge H Medina
Aug 27, 2013·Neurobiology of Learning and Memory·Thomas J Gould, Prescott T Leach
Feb 27, 2004·Physiology & Behavior·Tomoaki SatoTakashige Nishikawa
Feb 9, 2002·European Journal of Pharmacology·Jos PrickaertsArjan Blokland
Dec 11, 1999·European Journal of Pharmacology·M El-GhundiS R George
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Jul 13, 2000·Brain Research. Molecular Brain Research·G ParatchaJ H Medina

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