PMID: 6171740Jan 1, 1981Paper

Involvement of hippocampal serotonergic activity in age-related changes in exploratory behavior

Neurobiology of Aging
M J BrennanE Friedman

Abstract

The effect of aging on exploratory behavior was investigated in adult (5 month) and aged (28 month) CB6F1 mice. During the first 10 minutes of the test session, aged mice made fewer head dip responses and spent less time exploring the novel stimuli. Because the aged mice were observed to subsequently increase their duration of exploration, it was suggested that the initial differences in exploration reflected a suppression of exploratory behavior by the aged mice. Immediately after behavioral testing, mice were sacrificed and hippocampal serotonin (5HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were determined. While 5HT concentrations were not found to be significantly altered with age, significant increases in 5-HIAA concentrations and in the ratio of 5-HIAA/5HT were observed in the aged mice. Further, the elevation in the 5-HIAA/5HT ratio was found to be significantly correlated with age-related differences in the duration, but not the frequency, of head dip responses. In view of this finding, it was suggested that alterations in serotonergic function with age may selectively affect specific aspects of an animal's response to novel stimuli.

References

Sep 1, 1979·Psychopharmacology·M A GeyerR L Hawkins
Feb 1, 1977·Pharmacology, Biochemistry, and Behavior·S E File
Feb 1, 1979·Journal of Comparative and Physiological Psychology·J S Fink, G P Smith
Oct 14, 1975·Psychopharmacologia·S E File, A G Wardill
Mar 30, 1973·Brain Research·C E Finch
Apr 21, 1967·Science·G K AghajanianM H Sheard
Mar 1, 1972·Physiology & Behavior·J A Rosecrans, M D Schechter
Sep 1, 1971·Journal of Comparative and Physiological Psychology·D A Feigley, L W Hamilton
Feb 1, 1981·Behavioral and Neural Biology·P Kubanis, S F Zornetzer
Jun 1, 1980·Pharmacology, Biochemistry, and Behavior·C C LoullisM H Aprison
Jan 1, 1981·Neurobiology of Aging·K A ShermanE Friedman
Jan 1, 1980·Neurobiology of Aging·A S LippaR T Bartus
Jan 1, 1980·Neurobiology of Aging·R StrongS J Enna
Jan 1, 1981·Behavioral and Neural Biology·S M Fraley, A D Springer
Oct 1, 1980·Behavioral and Neural Biology·M A GeyerG J Rose
Nov 1, 1980·Journal of Neurochemistry·M S Benedetti, P E Keane

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Citations

Nov 1, 1987·Neurochemical Research·A MorettiF Trunzo
Dec 31, 1991·Mechanisms of Ageing and Development·F AmentaW L Collier
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·M J Forster
Oct 1, 1995·Brain Research. Molecular Brain Research·B MeisterB Ulfhake
Sep 1, 1984·Behavioral and Neural Biology·M J BrennanD Quartermain
Sep 1, 1984·Behavioral and Neural Biology·H KametaniK Inoue
Jan 30, 2016·Molecular Brain·Hirotaka ShojiTsuyoshi Miyakawa
Jan 28, 2016·Frontiers in Zoology·Vera BrustLars Lewejohann
Nov 1, 1985·Journal of Neurochemistry·J A SeversonB Winblad
Jan 1, 1984·Journal of Pineal Research·I M McIntyre, G F Oxenkrug
Nov 1, 1990·Thrombosis Research·M H PietraszekA Takada
Dec 1, 1984·Journal of Neurochemistry·J MarcussonB Winblad
Jan 1, 1984·Neuroradiology·J RuscalledaM de Juan
Jan 1, 1985·Neuroradiology·J M StevensB E Kendall
May 21, 2013·Physiology & Behavior·Winanda W UrsinusCornelis G van Reenen

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