Involvement of histamine receptors in the acquisition of inhibitory avoidance in Carassius auratus

Progress in Neuro-psychopharmacology & Biological Psychiatry
Luciana Pereira do Vale Cofiel, Rosana Mattioli

Abstract

This study investigated the involvement of H(1) and H(2) histaminegic receptors on the acquisition of a new task in Carassius auratus by using an inhibitory avoidance paradigm in which the animals had to learn to avoid an aversive stimulus. Before training, the fish received injections of H(2) antagonist zolantidine at a dose of 20 mg/kg, or H(1) antagonist chlorpheniramine at a dose of 4 or 16 mg/kg. Control animals were injected with distilled water. A facilitatory effect of chlorpheniramine was observed at the dose of 16 mg/kg. On the other hand, the administration of 20 mg/kg of zolantidine inhibited acquisition. Place preference conditioning was used to observe the aversive or reinforcing effects of the drugs, which could interfere with the inhibitory avoidance procedure; however, no effects were observed. Thus, it can be suggested that both receptors, H(1) and H(2), are involved in the acquisition of a new task in this species.

References

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Citations

Oct 3, 2008·Neuropsychiatric Disease and Treatment·J D Best, Wendy K Alderton
Jun 24, 2010·Critical Reviews in Toxicology·Giuseppina GiusiMarcello Canonaco
Apr 20, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K R SerafimR Mattioli
Mar 31, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D C GarçãoR Mattioli
May 20, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F R Faganello, R Mattioli
Mar 22, 2007·Expert Opinion on Therapeutic Targets·Andrea Brambilla, Paola Tarroni

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