Involvement of histone hypoacetylation in Ni2+-induced bcl- 2 down-regulation and human hepatoma cell apoptosis

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Jiuhong KangQing Liu

Abstract

Although induction of cell apoptosis is known to be involved in the cytotoxicity of Ni(2+), little research has been aimed at the mechanism of Ni(2+)-induced apoptosis. Recent studies showed that Ni(2+) induces histone hypoacetylation in different cell lines. Since histone hypoacetylation plays important roles in the control of cell cycle progress and apoptosis, we hypothesized that histone hypoacetylation may be an unrevealed pathway in Ni(2+)-induced apoptosis. To address this, effects of Ni(2+) on cell apoptosis, bcl- 2 gene expression and histone acetylation were examined in human hepatoma Hep3B cells. We found that Ni(2+) treatment resulted in cell proliferation arrest, the appearance of detached cells, condensed chromatin, apoptotic bodies and specific DNA fragmentation, indicating the occurrence of cell apoptosis. At the same time, Ni(2+) induced a significant decrease in bcl- 2 expression and histone acetylation; the decrease of histone H4 acetylation in nucleosomes associated with the bcl- 2 promoter region was also proven by a chromatin immunoprecipitation assay, indicating the involvement of histone hypoacetylation in Ni(2+)-induced bcl- 2 down-regulation. Further studies showed that increasing histone acetylation by...Continue Reading

References

Jun 1, 1992·Trends in Pharmacological Sciences·W BurschR Schulte-Hermann
Oct 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P J HaleyC H Hobbs
Jun 1, 1986·British Journal of Industrial Medicine·Z C Shi
Apr 1, 1984·Environmental Research·R J SmialowiczG A Stott
Jun 6, 1994·The Science of the Total Environment·Z Shi
Jun 3, 1994·Journal of Immunological Methods·W G TelfordP J Fraker
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z AranyD M Livingston
Jan 1, 1997·Environmental and Molecular Mutagenesis·S LynnK Y Jan
May 8, 1998·Biochemical and Biophysical Research Communications·S G Gray, T J Ekström
Sep 12, 1998·Science·J M Adams, S Cory
Oct 30, 1998·Biochemical and Biophysical Research Communications·J F HuA R Hoffman
Jan 5, 1999·Experimental & Molecular Medicine·S H LeeM H Cho
Mar 19, 1999·Molecular and Cellular Biology·A S ClarkeL Pillus
May 14, 1999·Current Opinion in Genetics & Development·S Y Archer, R A Hodin
Dec 2, 1999·Methods : a Companion to Methods in Enzymology·M H Kuo, C D Allis
May 10, 2000·Current Opinion in Cell Biology·W L CheungC D Allis
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Mar 21, 2001·Human Molecular Genetics·S B BaylinJ G Herman
Sep 13, 2001·Biochimica Et Biophysica Acta·A Klochendler-Yeivin, M Yaniv
Mar 9, 2002·Science·Christopher J Fry, Craig L Peterson
Mar 30, 2002·Critical Reviews in Oncology/hematology·E Denkhaus, K Salnikow
Mar 30, 2002·Critical Reviews in Oncology/hematology·Fei Chen, Xianglin Shi
Nov 12, 2002·Environmental Health Perspectives·Yi HuangChuanshu Huang
Dec 4, 2002·Toxicology and Applied Pharmacology·Kyungtae KimKazimierz S Kasprzak
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jiuhong KangYingxian Ou
Jul 3, 1954·Journal of the American Medical Association·F W SUNDERMAN, J F KINCAID
Oct 25, 2003·Toxicology and Applied Pharmacology·Qunwei ZhangMax Costa
Feb 21, 2004·Biochemical and Biophysical Research Communications·Teruhisa KawamuraToru Kita

❮ Previous
Next ❯

Citations

Jul 6, 2007·Journal of Cancer Research and Clinical Oncology·Xueli BaiShusen Zheng
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Chang-Yu ChenMiao-Chen Chou
May 14, 2014·Cell Biochemistry and Biophysics·Hasan Aksit, Aysegül Bildik
Jan 26, 2016·Environmental Toxicology and Pharmacology·Yoon-Jin LeeSang-Han Lee
Dec 26, 2015·International Journal of Molecular Sciences·Hongrui GuoBangyuan Wu
Oct 13, 2009·Medical Hypotheses·Melissa S NiseThomas C Erren
Dec 31, 2008·Mutation Research·Rodrigo FrancoMihalis I Panayiotidis
Mar 30, 2005·Biochemical Pharmacology·Jiuhong KangYuntao Zhang
Apr 9, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jiuhong KangZhenhua Wang
Jan 25, 2020·International Journal of Environmental Research and Public Health·Giuseppe GenchiAlessia Catalano
Feb 15, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Ahmad SalimiNahid Etefaghi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Jiuhong KangZhenhua Wang
Mutation Research
Marisa D Pulido, Alan R Parrish
© 2022 Meta ULC. All rights reserved